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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15371 | Gardiquimod | TLR , HIV Protease | |
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells... | |||
T12079 | ML604440 | Proteasome | |
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor. | |||
T11465 | Lenacapavir | GS-6207 | Others , HIV Protease |
Lenacapavir (GS-6207) is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells. | |||
T2384 | Pomalidomide | CC-4047 | Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues |
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator. | |||
T8311 | Obefazimod | ABX-464,ABX464 | HIV Protease |
Obefazimod (ABX-464) is a potent anti-HIV agent. ABX464 inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) (IC50 : 0.1 μM - 0.5 μM) | |||
T37292 | M62812 | TLR | |
TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic sh... | |||
TQ0174 | Mavorixafor | AMD-070 | CXCR |
Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC... | |||
T28946 | Tenofovir exalidex | Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157 | Antiviral |
Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant HIV strains, including those resistant to multiple nucleosi... | |||
T11035 | DiABZI STING agonist-1 (Tautomerism) | diABZI STING agonist (Compound 3) | STING |
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. | |||
T10296 | Mavorixafor trihydrochloride | AMD-070 trihydrochloride | HIV Protease |
Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (I... | |||
TQ0297 | Cenicriviroc | TAK-652,TBR-652 | HIV Protease , CCR |
Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity. | |||
T74062 | PROTAC IRAK4 degrader-2 | ||
PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs). It also notably decreases IRAK4 protein levels... | |||
T27967 | M199 | ||
M199, a novel inhibitor of TLR3/9 activation, induces secretion of IL-6, IL-8 and TNFalpha in human PBMCs. | |||
T83698 | Cathelicidin-2 (128-153) (chicken) TFA | Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153) | |
Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globi... | |||
T27030 | CK176 | HIV-1 inhibitor-34,HIV-1 inhibitor 34,CK 176,CK-176,HIV-1 inhibitor34 | |
CK176 is a capsid targeted inhibitor of HIV-1 replication. CK176 shows an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs). | |||
T63329 | PD-1/PD-L1-IN-25 | ||
PD-1/PD-L1-IN-25 is an inhibitor of PD-1/PD-L1 interaction (IC50: 16.17 nM) that effectively activates anti-tumor immunity of T cells in PBMCs. PD-1/PD-L1-IN-25 can be used to study cancer. | |||
T77851 | INX-SM-6 | ||
INX-SM-6, a chemical compound, serves as a targeted delivery vehicle for anti-inflammatory agents and has shown efficacy in suppressing LPS-induced IL-1β production in human PBMCs [1]. | |||
T70881 | Dolutegravir RR Isomer | ||
Dolutegravir RR Isomer is an isomer of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mono... | |||
T74915 | ODN D-SL03 | ||
ODN D-SL03, a class C CpG oligonucleotide, effectively stimulates peripheral blood mononuclear cells (PBMCs) to produce high levels of IFN-α. It activates human B cells, NK cells, and mononuclear cells, elevating the exp... | |||
T71009 | Dolutegravir SR Isomer | ||
Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripher... |