mitochondrial autophagy — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5S1099	Liensinine		Apoptosis , Mitophagy , Others , Autophagy
	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.		Apoptosis , Mitophagy , Others , Autophagy
T1907	Mdivi-1	Mitochondrial division inhibitor 1	Apoptosis , Mitophagy , Dynamin , Autophagy
	Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.		Apoptosis , Mitophagy , Dynamin , Autophagy
T6468	D-glutamine		Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy
	D-Glutamine is the D-type stereoisomer of cell-permeable glutamine, one of the 20 amino acids encoded by the standardized genetic code.
T0595	Naringin	Naringoside	Mitophagy , P450 , Endogenous Metabolite , Autophagy
	Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.		Mitophagy , P450 , Endogenous Metabolite , Autophagy
T1554	Iohexol		Mitophagy , Autophagy
	Iohexol is an X-ray contrast agent containing varying concentrations of iohexol, which can be used for a variety of imaging applications.		Mitophagy , Autophagy
T0876	Clioquinol	Chinoform,Iodochlorhydroxyquin	Mitophagy , Antibiotic , Autophagy , Antifungal
	Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.		Mitophagy , Antibiotic , Autophagy , Antifungal
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T5515	Hemin	Hemin chloride	Mitophagy , Ferroptosis , Autophagy
	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini...		Mitophagy , Ferroptosis , Autophagy
T2140	Parthenolide	(-)-Parthenolide	Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.		Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
T2174	Quercetin	Sophoretin	Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy
	Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inh...
T3028	Tripterin	Celastrol,Tripterine	Apoptosis , Mitophagy , Proteasome , Autophagy
	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula...		Apoptosis , Mitophagy , Proteasome , Autophagy
T8526	Metformin	1,1-Dimethylbiguanide	Mitophagy , AMPK , Autophagy
	Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm...		Mitophagy , AMPK , Autophagy
T2414	Torkinib	PP 242	Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
	Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).		Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
T0649	Salicylic acid	2-Hydroxybenzoic acid	Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy
	Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T0943	Carbamazepine	NSC 169864	Mitophagy , Sodium Channel , Autophagy
	Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna...		Mitophagy , Sodium Channel , Autophagy
T2177	Kaempferol	Kempferol,Robigenin	Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy
	Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
T6641	Rilmenidine Phosphate		Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor
	Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.
T0972	Isoniazid	INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide	Mitophagy , Dehydrogenase , CAT , Antibacterial , Autophagy
	Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.		Mitophagy , Dehydrogenase , CAT , Antibacterial , Autophagy
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T4S1102	Liensinine diperchlorate	Liensinine-Perchlorate	Mitophagy , Others , Autophagy
	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...		Mitophagy , Others , Autophagy