264.7

Flunixin meglumine (Banamine) is an effective inhibitor of the enzyme cyclooxygenase with anti-inflammatory and antipyretic activity.

Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Dexamethasone palmitate is a glucocorticoid receptor agonist and an anti-inflammatory agent.

Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.

Telithromycin is a semisynthetic 14-membered macrolide antibiotic and erythromycin derivative that binds to the 50S subunit of the 70S bacterial ribosome, inhibits bacterial protein synthesis, and exhibits antimicrobial activity against a wide range of gram-positive and gram-negative bacteria for the treatment of mild to moderate respiratory infections.

Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX-2, and PPAR-γ. In LPS-stimulated RAW 264.7 macrophages, it exerts anti-inflammatory activity by inhibiting the ERK signaling pathway.

NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.

BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound

Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μM).

Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,

7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) exhibits anti-inflammatory, antibacterial, and antifungal activities, along with moderate antitrypanosomal activity, having an MIC value of 19.0 µg/mL.

Dactylorhin A, a succinate derivative ester isolated from the rhizomes of Gymnadenia conopsea, exhibits a moderate inhibitory effect on nitric oxide (NO) production in RAW 264.7 macrophage cells.

Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide) exhibits antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells.

Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.

Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzquinamide for α2A, α2B, and α2C adrenergic receptor (α2-AR) were 1,365, 691, and 545 nM, respectively. 545 nM, respectively.

Anti-IGF-2 Antibody (DX-2647) is a human antibody produced in CHO cells, targeting IGF-2. It carries a huIgG1 heavy chain and a huκ light chain, with an estimated molecular weight (MW) of 145.78 kDa. For isotype control, refer to Human IgG1 kappa, Isotype Control.

Motilin (26-47), human and pig are endogenous Motilin receptor ligands in Chinese hamster ovarian cell lines, with Ki and EC50 at 2.3 nM and 0.3 nM, respectively.

Compound Fr12647, with CAS No. 175135-89-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr12647 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

BE2647 is a selective inhibitor of the mitochondrial pyruvate carrier (MPC), with an EC50 of 70 nM. It exhibits good metabolic stability in mouse liver microsomes. BE2647 can be utilized in research related to metabolic diseases, metabolic-associated steatotic liver disease (MASLD), or metabolic-associated steatohepatitis (MASH).

JNJ-40264796 is a negative control for JNJ-40068782.

Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.

GSK2647544 is an orally active selective inhibitor of Lp-PLA2, a calcium non-dependent phospholipase A2 secreted primarily by monocyte-derived macrophages that exhibits pro-inflammatory effects.

NUN82647 (CU-242) is an Inhibitor of cell cycle at G2 phase, and apoptosis inducer.

JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity (IC50=7.1 μM) but does not affect IκBα degradation. JSH-23 is an antioxidant with anti-inflammatory activity.

C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNβ production and possesses anti-inflammatory activity.