β-glucan

Lentinan, isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.

Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers.

Fusacandin B inhibits (1,3)-β-glucan synthase and possesses antifungal properties.

Fusacandin A inhibits (1,3)-β-glucan synthase and exhibits antifungal properties.

Pneumocandin A1 is a lipopeptide antibiotic with potent anti-candidal activity. It inhibits 1,3-β-glucan synthesis in vitro, with an IC50 range of 0.07-0.5 μg/mL.

Pneumocandin A4 is a lipopeptide antibiotic with potent activity against Candida species. It inhibits 1,3-β-D-glucan synthesis in vitro, with an IC50 ranging from 0.07 to 0.5 μg/mL.

Arborcandin D is a 1,3-β-glucan synthase inhibitor that functions as an antifungal antibiotic. It exhibits IC50 values of 3 μg mL against Candida albicans (C. albicans) and 0.35 μg mL against Aspergillus fumigatus (A. fumigatus). The minimum inhibitory concentration (MIC) of Arborcandin D for Candida species is 4 μg mL.

Arborcandin B is an inhibitor of 1,3-β-glucan synthase and serves as an antifungal antibiotic. The IC50 values of Arborcandin B for Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus) are 0.30 μg mL and 0.025 μg mL, respectively. The minimum inhibitory concentration (MIC) for Candida species is 2-4 μg mL.

Arborcandin F, a 1,3-β-glucan synthase inhibitor, serves as an antifungal antibiotic. It exhibits IC50 values of 0.012 μg mL against Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus). For Candida species, the minimum inhibitory concentration (MIC) of Arborcandin F ranges from 0.25 to 1 μg mL.

Arborcandin E is a 1,3-β-glucan synthase inhibitor used as an antifungal antibiotic. It exhibits IC50 values of 0.1 μg mL against Candida albicans (C. albicans) and 0.012 μg mL against Aspergillus fumigatus (A. fumigatus). Additionally, Arborcandin E has a MIC of 0.5-2 μg mL for Candida species.

Arborcandin A is a 1,3-β-glucan synthase inhibitor, acting as an antifungal antibiotic. It exhibits IC50 values of 0.25 μg mL against Candida albicans (C. albicans) and 0.05 μg mL against Aspergillus fumigatus (A. fumigatus). The MIC for the Candida species is 4-8 μg mL.

Arborcandin C is an inhibitor of 1,3-β-glucan synthase, functioning as an antifungal antibiotic. It exhibits IC50 values of 0.15 μg mL against Candida albicans (C. albicans) and 0.015 μg mL against Aspergillus fumigatus (A. fumigatus). The compound's minimum inhibitory concentration (MIC) for Candida species ranges from 1-2 μg mL.