β-glucan

Lentinan, isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.

Carboxymethyl β-glucan is a derivative of β-glucan with immunostimulatory properties. Carboxymethyl β-glucan can be utilized in the synthesis of nanocarriers.

β-Glucan-transporting ATPase (EC 7.5.2.3) is useful for studying the role of β-glucan transport ATPases in carbohydrate transport research.

1,3-β-Glucan synthase (EC 2.4.1.34) is a member of the glycosyltransferase family, specifically classified as a hexosyltransferase.

Whole Glucan Particles act as agonists for Dectin-1a and enhance the innate immune system by improving the functionality of immune cells such as macrophages and monocytes.

α-1,4-Glucan-protein synthase (ADP-forming) (EC 2.4.1.113) catalyzes the construction of α-1,4-glucan chains that covalently bond with proteins, initiating glycogen synthesis.

1,3-β-D-Glucanphosphorylase (EC 2.4.1.97) acts on diverse β-1,3-oligoglucans and laminari-type glucans.

α-1,3-Glucan synthase (EC 2.4.1.183) requires a glucan primer to initiate the reaction, leading to the extension of the glucan chain.

1,4-α-Glucan branching enzyme (EC 2.4.1.18) converts amylose into amylopectin.

1,4-α-Glucan 6-α-glucosyltransferase (EC 2.4.1.24) is part of the glycosyltransferase family, specifically classified as a hexosyltransferase.

Rezafungin (SP-3025, Biafungin) is a natural product echinocandin and a 1,3-β-D-glucan synthase inhibitor with broad-spectrum antifungal activity, high tissue penetration, and a long half-life, used for the treatment of candidemia and invasive candidiasis.

D75-4590 is a β-1,6-Glucan inhibitor. As glucan is a major component of the cell wall, specifically β-1,6-Glucan, D75-4590 can fight fungal infections by inhibiting its synthetase.

Laminaran is a β-1,3-glucan isolated from brown algae, often serving as a typical ligand for Dectin-1. It possesses anti-cancer, immune-modulating, and radiation-protective properties. Laminaran can be catalyzed by glucanase. In in vitro and in vivo experiments, Laminaran has demonstrated anti-tumor activity and may be used for severe cancers.

β-D-Glucan is a compound that targets tumor-associated macrophages with antitumor activity and modulates the immune response in necrotizing pancreatitis.

β-1,3-Glucan is a major constituent of all characterized fungal cell walls, comprising 30% to 80% of wall mass, and β-1,3-Glucan exists as a branched polymer in the cell wall, with branches connected via β-1,6 linkages, enabling investigation into fungal structural biology, cell wall assembly, immunomodulation, and antifungal therapeutic targeting.

Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.

Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. This agent is active against Aspergillus and Candida species.

Anidulafungin (Ecalta) (LY303366) is an echinocandin derivative used as an antifungal drug. It inhibits glucan synthase activity.

α-Amylase, Human Saliva (1,4-alpha-D-Glucan-glucanohydrolase, ptyalin), is a biomaterial or organic compound utilized for research in the life sciences.

α-Amylase, Human Pancreas (Amylase, a-Amylase, 1,4-a-D-glucan glucanohydrolase, glycogenase) serves as a biological material or organic compound suitable for life sciences research.

D-Glucan is an orally active immune activator of the Dectin-1 receptor and possesses antioxidant properties (reduces TNF-α). It activates macrophages and neutrophils, eliminates free radicals, inhibits oxidative stress and inflammatory responses, and enhances insulin sensitivity. Additionally, D-Glucan enhances the activity of the antioxidant enzyme glutathione, inhibits gluconeogenesis, and activates GK, promoting glycolysis. It is applicable in research on liver injury protection (antagonizing Acetaminophen toxicity), radiation protection (in synergy with vitamin E), and diabetes (improving glucose metabolism).

TRITC-dextran MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) is a fluorescent dye with a molecular weight of 500 kD. It has an excitation wavelength of 555 nm. This compound is utilized in drug delivery due to the stability of TRITC across a broad pH range (pH 2–11) and its resistance to photobleaching.

TRITC-dextran MW 20000 is a fluorescent dye with a molecular weight of 20 kD and an excitation wavelength of 555 nm. This compound is capable of penetrating the vasculature and can be used to label plasma for visualizing the vascular system. Furthermore, TRITC-dextran MW 20000 is employed in drug delivery due to its stability across a wide pH range (pH 2–11) and its resistance to photobleaching.