α-cyano

α-Cyano-4-hydroxycinnamic acid (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1), which blocks pyruvate transport in rat heart mitochondria (IC50: 1.5 μM).

(Z)-p-cyano-α-Cyanostilbene (compound 11) is a phenanthrene derivative with antiproliferative activity, showing significant selectivity against HeLa (IC₅₀ = 0.21 μM) and HepG2 (IC₅₀ = 0.230 μM) cells, while not being cytotoxic to normal skin fibroblasts (IC₅₀ > 100 μM) [1].

(Z)-α-Cyanostilbene (compound 8), a dicyano-substituted acrylonitrile, exhibits selective antiproliferative effects on HeLa and HepG2 cells, with IC50 values of 0.33 and 0.52 μM, respectively [1].

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), a potent inhibitor of 12 15-Lipoxygenases (LO), shows potential in type 1 diabetes mellitus research [1].

4-Chloro-α-cyanocinnamic acid (Cl-CCA), a phenylpropanoid derivative of cinnamic acid synthesized from phenylalanine by plants, exhibits a propensity for co-crystallization with a range of biomolecules, including peptides and nucleic acids.

λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group. It is employed across various applications for controlling a wide array of pests. As a neurotoxin, λ-Cyhalothrin acts on sodium channels in neuron membranes within the central nervous system.