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PROTACPROTAC Selection
Selection of target proteins for PROTAC can be based on the following considerations: 1. Whether the protein is specific or not, non-specific proteins can cause off-target toxicity; 2. Whether the protein belongs to the molecules that can be degraded by PROTAC, and it has been reported that the targets that can be used for PROTAC include, kinases (MEK, KRAS, CDK, and Bcr/Abl), transcription factors (e.g. p53, STAT, RAR, ER, and AR), epigenetic factors (e.g., HDAC and BET bromodomain), and E3 ligases themselves (e.g., MDM2), among others; 3. Whether or not the protein has been reported to have a ligand or crystalline form that can be commercially engineered.
- Fmoc-PEAT17977329223-23-6In houseFmoc-PEA (Example 1-2) is utilized as a cleavable linker for antibody-drug conjugates (ADC).
- $43
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- tri-GalNAc-COOHT393701953146-81-0In houseTri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
- $255
SizeQTY - ARV-825T54341818885-28-7ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.
- $60
SizeQTY - MD-224T119802136247-12-4MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
- $64
SizeQTY - BSJ-03-123T53952361493-16-3BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.
- $84
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- Dbet57T54401883863-52-2dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2
- $42
SizeQTY - dBRD9 HClT31221L2341840-98-8dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degrader of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 HCl does not degrade BRD4 or BRD7 at concentrations up to 5 μM. dBRD9 HCl displays antiproliferative effects in human AML cell lines.
- $197
SizeQTY - UNC6852T139542688842-08-0UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
- $135
SizeQTY - THAL-SNS-032T170692139287-33-3THAL-SNS-032 is a PROTAC designed to selectively degrade CDK9.
- $118
SizeQTY - dBET6T51301950634-92-0dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
- $48
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Cited - TD-165T187872305936-56-3TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
- $116
SizeQTY - ARV-771T54351949837-12-0ARV-771 is a potent BET degrader based on PROTAC technology, with Kds of 34 nM for BRD2(1), 4.7 nM for BRD2(2), 8.3 nM for BRD3(1), 7.6 nM for BRD3(2), 9.6 nM for BRD4(1), and 7.6 nM for BRD4(2), respectively[1].
- $55
SizeQTY - VH032T291061448188-62-2In houseVH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs, which can recruit von Hippel-Lindau (VHL) proteins as a ligand of VHL.
- $44
SizeQTY - dBET1T44951799711-21-9dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
- $48
SizeQTY - Gefitinib-based PROTAC 3T54372230821-27-7Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].
- $38
SizeQTY - dTRIM24T151782170695-14-2dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.
- $129
SizeQTY - JQAD1T411802417097-18-6JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a cereblon E3 ligase ligand. JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner. JQAD1 suppresses both H3K27ac and EP300 expression levels and induces apoptosis. JQAD1 suppresses tumors growth in NSG mice xenografted with Kelly cells. CRC and MYCN genes are downregulated in tumors treated with JQAD1. JQAD1 exhibits no significant effect on coactivator CBP at concentrations inducing EP300 degradation.
- $131
SizeQTY Cited - ACBI1T173502375564-55-7ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
- $59
SizeQTY - GSK215T678432743427-26-9GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation.
- $127
SizeQTY - dCeMM2T61477296771-07-8dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.
- $31
SizeQTY - MS4078T161532229036-62-6MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.
- $44
SizeQTY - Homo-PROTAC pVHL30 degrader 1T137222244684-49-7Homo-PROTAC pVHL30 degrader 1 is a potent PROTAC-based degrader of pVHL30.
- $29
SizeQTY - dCeMM1T67778118719-16-7dCeMM1, a RBM39 glue degrader, re-directs the activity of the CRL4DCAF15 ligase and decreases RBM39 expression levels in WT KBM7 cells.
- $32
SizeQTY - Homo-PROTAC cereblon degrader 1T137212244520-98-5Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
- $228
SizeQTY - A1874T54422064292-12-0A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
- $228
SizeQTY - dMCL1-2T136572351218-88-5In housedMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.
- $3,200
SizeQTY - FKBP12 PROTAC dTAG-7T112922064175-32-0In houseFKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by linking BET bromodomains to the E3 ubiquitin ligase CRBN. It also functions as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
- $1,280
SizeQTY - QCA570T167012207569-08-0In houseQCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).
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SizeQTY - cis VH 032, amine dihydrochlorideT354782376990-32-6cis VH 032, amine dihydrochloride ((S,S,S)-AHPC) is a negative control for the functionalized VHL ligand VH 032, amine .
- $51
SizeQTY - BETd-260T145502093388-62-4In houseBETd-260, a PROTAC linked by a Cereblon ligand and a BET ligand, has an inhibitory effect on BRD4 protein in leukemic cell lines.
- $132
SizeQTY - β-NF-JQ1T105262380000-55-3In houseβ-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. Using β-NF as an AhR ligand, it targets bromodomain (BRD)-containing proteins and induces AhR and BRD protein interactions. β-NF-JQ1 exhibits potent anticancer activity associated with protein knockdown activity.
- $97
SizeQTY - MT-802T161572231744-29-7MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1 nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL).
- $88
SizeQTY - ARV-393T843162851885-95-3ARV-393 is a BCL6 PROTAC degrader with DC50 and GI50 values of <1 nM in both DLBCL and BL cell lines. ARV-393 inhibits tumor volume in multiple tumor xenograft models.
- $268
SizeQTY - PROTAC BRD4 Degrader-1T138332133360-00-4PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
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SizeQTY - TD-428T13105TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation.
- Inquiry Price
SizeQTY - Halo PROTAC 1T179952241668-45-9Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce autophagy of an intracellular molecule are linked via a PEG linker[1].
- Inquiry Price
SizeQTY - PROTAC EED degrader-2T12554PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27) and an inhibitor of polycomb repressive complex 2 (PRC2) with a pIC50 of 8.11.
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SizeQTY - PROTAC FKBP Degrader-3T186102079056-43-0PROTAC FKBP Degrader-3 is a potent FKBP degrader, consisting of a FKBP ligand binding group, a linker, and a VHL binding group [1].
- $493
SizeQTY - KB02-JQ1T180602384184-44-3KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modification of the E3 ligase DCAF16, thereby promoting BRD4 degradation. Importantly, KB02-JQ1 demonstrates enhanced stability and durability in facilitating protein degradation within biological systems. The compound forms a complex with the ubiquitin E3 ligase ligand KB02 through a linker, resulting in the formation of KB02-JQ1[1].
- Inquiry Price
SizeQTY - VH032-PEG5-C6-ClT179961799506-06-1VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule that includes the VH032-based VHL ligand and a 5-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
- Inquiry Price
SizeQTY - PROTAC B-Raf degrader 1T125562364367-27-9PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
- $431
SizeQTY - PROTAC BET Degrader-1T138492093386-22-0PROTAC BET Degrader-1 is a potent BET degrader utilizing the PROTAC mechanism.
- $456
SizeQTY - PROTAC FLT-3 degrader 1T125552230826-81-8PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD) with an IC50 of 0.6 nM and exhibits anti-proliferative activity.
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SizeQTY - MZP-54T137852010159-47-2MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
- $456
SizeQTY - BETd-246T145492140289-17-2BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.
- $539
SizeQTY - PROTAC MDM2 Degrader-4T186342249750-24-9PROTAC MDM2 Degrader-4, designed using PROTAC technology, combines a potent MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase to degrade MDM2[1].
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SizeQTY - PROTAC CRBN Degrader-1T186042358775-70-7PROTAC CRBN Degrader-1 is a chemical compound consisting of a cereblon (CRBN) ligand binding group, a linker, and a von Hippel-Landau (VHL) binding group. It functions as a cereblon (CRBN) degrader[1].
- $987
SizeQTY - (S,R,S)-AHPC-PEG6-C4-ClT179261835705-59-3(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC comprising the (S,R,S)-AHPC based VHL ligand and a 6-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
- $61
SizeQTY - PROTAC ERα Degrader-1T18636PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as a degrader of estrogen receptor-alpha (ERα).
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