PROTAC Selection

Cat. No.	Product name	CAS No.	Purity
T61477	DCeMM2	296771-07-8	98%
T61477	dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K...
T29106	VH032	1448188-62-2	98%
T29106	VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs...
T17977	Fmoc-PEA	329223-23-6	98%
T17977	Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).
T10526	β-NF-JQ1	2380000-55-3	98%
T10526	β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BR...
T39370	Tri-GalNAc-COOH	1953146-81-0	98%
T39370	Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
T14550	BETd-260	2093388-62-4	98%
T14550	BETd-260, a PROTAC linked by a Cereblon ligand and a BET ligand, has an inhibitory effect on BRD4 protein in leukemic cell lines.
T31221L	DBRD9 HCl	2341840-98-8	98%
T31221L	dBRD9 HCl is a PROTAC composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide . dBRD9 HCl is a potent and selective degra...
T16667	PROTAC Sirt2 Degrader-1	2098487-75-1	98%
T16667	PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
T17249	VZ185	2306193-61-1	98%
T17249	VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
T11292	FKBP12 PROTAC dTAG-7	2064175-32-0	98%
T11292	FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin l...
T5438	PROTAC CDK9 Degrader-1	2118356-96-8	98%
T5438	PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
T13839	PROTAC ER Degrader-4	2361114-15-8	98%
T13839	PROTAC ER Degrader-4 is a PROATC degrader of estrogen receptor (ER)(IC50 of 0.8 nM).
T11664	INY-03-041	T11664	98%
T11664	INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively. INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT ...
T12556	PROTAC B-Raf degrader 1	2364367-27-9	98%
T12556	PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
T13846	PROTAC RIPK degrader-2	1801547-16-9	98%
T13846	PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
T13849	PROTAC BET Degrader-1	2093386-22-0	98%
T13849	PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
T18631	PROTAC MDM2 Degrader-1	2249944-98-5	98%
T18631	PROTAC MDM2 Degrader-1 is a chemical compound that utilizes PROTAC technology to degrade MDM2. This compound is comprised of a highly effective MDM2 inhibitor, a...
T18633	PROTAC MDM2 Degrader-3	2249750-23-8	98%
T18633	PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 l...
T18607	PROTAC ER Degrader-3	2158322-29-1	98%
T18607	PROTAC ER Degrader-3, an intermediate for the synthesis of PAC, is a compound derived from patent WO2017201449A1, specifically compound LP2. PAC serves as the li...
T17910	(S,R,S)-AHPC-PEG2-C4-Cl	1835705-57-1	98%
T17910	(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capa...