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Lung Cancer Modeling

Lung cancer is a leading cause of cancer-related deaths worldwide and is classified into two major types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Common modeling approaches include transgenic technologies, carcinogen exposure, and patient-derived tumor xenografts, which effectively mimic tumor formation and metastasis in the lungs. These models are widely used in the study of immunotherapy, targeted therapy, and early diagnostic biomarkers for lung cancer.

NNK
Nicotine-derived nitrosamine ketone
T2053364091-91-4
NNK is a nitrosated derivative of nicotine that activates the ERK1/2 and PKCα signaling pathways, induces Bcl2 phosphorylation at Ser70, and activates c-Myc at Thr58 and Ser62, thereby promoting the proliferation and survival of human lung cancer cells, and is commonly used to establish lung cancer mouse models.
  • $35
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Benzo[a]pyrene
3,4-Benzopyrene
T698550-32-8
Benzo[a]pyrene (3,4-Benzopyrene) exhibits lung carcinogenicity in animal models and is commonly used for lung cancer modeling and chemoprevention research.
  • $30
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Urethane
Ethylurethane, Ethyl carbamate, Carbamic acid ethyl ester
T005151-79-6
Urethane (Ethyl carbamate; Ethylurethane) is a byproduct formed during the fermentation process of various foods. As an ethyl ester of carbamic acid, it has the ability to inhibit the growth of bacteria, sea urchin eggs, protozoa, and plant tissues, and is commonly used for establishing lung cancer models.
  • $29
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DMBA
7,12-DMBA, 7,12-Dimethylbenzanthracene, 7,12-Dimethylbenz[a]anthracene
T3669657-97-6
DMBA (7,12-Dimethylbenz[a]anthracene) is a carcinogenic polycyclic aromatic hydrocarbon (PAH) that can be used to induce animal models of leukemia, liver cancer, breast cancer, skin cancer, and lung cancer. It is also capable of inducing programmed cell death (apoptosis) in A20.1 murine B-cell lymphoma.
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