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Colorectal cancer (CRC) has been experiencing a steady increase in incidence, particularly among middle-aged and elderly populations. Its pathogenesis involves multiple genetic mutations, including APC, KRAS, and TP53. Common modeling methods include AOM/DSS chemical induction, transgenic models, and patient-derived xenograft (PDX) models. These models are of significant value in studying the tumor immune microenvironment, inflammation-driven carcinogenesis, and in evaluating anticancer drug efficacy for colorectal cancer.
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