Skin Cancer Modeling Products

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Cancer Modeling

Breast Cancer Modeling

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Colorectal cancer Modeling

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Gastric Cancer Modeling

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Kidney Cancer Modeling

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Liver Cancer Modeling

Skin Cancer Modeling

Skin Cancer, including basal cell carcinoma, squamous cell carcinoma, and malignant melanoma, is a major focus of oncology research—particularly melanoma, due to its high invasiveness and metastatic potential. Common animal modeling methods include chemical carcinogenesis, ultraviolet (UV) induction, spontaneous models, and tumor cell line implantation. These models are widely used to study the pathogenesis of skin cancer, anti-tumor immune responses, and the evaluation of novel therapeutic strategies such as immune checkpoint inhibitors.

DMBA

T3669657-97-6

DMBA (7,12-Dimethylbenz[a]anthracene) is a carcinogenic polycyclic aromatic hydrocarbon (PAH) that can be used to induce animal models of leukemia, liver cancer, breast cancer, skin cancer, and lung cancer. It is also capable of inducing programmed cell death (apoptosis) in A20.1 murine B-cell lymphoma.

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Terephthalic acid

T8031100-21-0

Terephthalic acid is an isomer and a precursor of the polyester PET. It is used in the production of textiles and plastics, and can also be used to establish skin cancer models.

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Okadaic acid

T1638178111-17-8

Okadaic acid is a potent polyether marine toxin that primarily accumulates in the digestive glands of marine mollusks. It is a highly effective and selective inhibitor of protein phosphatases (PPs). By inhibiting these phosphatases, okadaic acid increases the phosphorylation levels of various proteins, acts as a tumor promoter, and induces tau protein phosphorylation. It can be used to establish models of Alzheimer’s disease and skin cancer.

$200

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Okadaic acid ammonium salt

T39183175522-42-6

Okadaic acid ammonium salt is a marine toxin that acts as an inhibitor of protein phosphatases (PP), with the highest affinity for PP2A (IC50 = 0.1–0.3 nM), while also inhibiting PP1, PP3, PP4, and PP5, but not PP2C. By increasing the phosphorylation of various proteins, it functions as a tumor promoter and induces tau protein phosphorylation, commonly used to establish Alzheimer's disease models.

$1,520

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