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Other Tumor Modeling

In addition to common solid tumors, glioma, pancreatic cancer, prostate cancer, and ovarian cancer also hold significant clinical relevance. Tumor modeling techniques include chemical carcinogenesis, transgenic engineering, patient-derived xenografts (PDX), organoid structures, and 3D organoid models. These diverse approaches provide robust support for precision therapy and mechanistic studies across various tumor types.

N-Ethyl-N-nitrosourea
T203564759-73-9
N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. It induces leukemia by alkylating nucleobases, thereby damaging DNA, which leads to bone marrow suppression and the development of leukemia cells. ENU is teratogenic in vivo, causing tumor formation and foot malformations in pregnant rats. Additionally, it can result in central nervous system (CNS) tumors and genetic disorders.
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10-14 weeks
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N,N'-Dinitrosopiperazine
T81720140-79-4
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine, DNP) is a known carcinogen associated with the development and metastasis of nasopharyngeal carcinoma. Its carcinogenic mechanism involves multiple signaling pathways, particularly exerting effects through the regulation of phosphorylation at the Ser568 site of the LYRIC protein. It can be used to induce esophageal cancer models.
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8-10 weeks
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