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Pulmonary Fibrosis Modeling

Pulmonary fibrosis is a severe lung disease characterized by excessive proliferation of the pulmonary interstitium and collagen deposition. Commonly used models, such as intratracheal instillation of bleomycin, simulate key processes including inflammation initiation and extracellular matrix accumulation. These models are widely applied in in vivo efficacy studies of anti-fibrotic therapies.

Bleomycin Sulfate
T61169041-93-4
Bleomycin sulfate is a glycopeptide antibiotic with antitumor activity. It is commonly used as a DNA-damaging agent and DNA synthesis inhibitor. It functions by inducing DNA strand breaks without affecting RNA strands. Bleomycin sulfate is widely used in cancer research and for establishing pulmonary fibrosis animal models.
  • $37
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Bleomycin hydrochloride
T6116L67763-87-5
Bleomycin hydrochloride is a glycopeptide antibiotic and a DNA synthesis inhibitor. Bleomycin Sulfate can cause DNA strand breaks but not RNA strand breaks. Bleomycin Sulfate has anti-tumor activity.
  • $37
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Amiodarone
T213701951-25-3
Amiodarone is an antiarrhythmic compound that inhibits ATP-sensitive potassium channels (IC₅₀ = 19.1 μM) and can induce pulmonary toxicity. It has shown some antiviral activity in diseases caused by SARS-CoV-2 and is commonly used to establish animal models of pulmonary fibrosis.
  • $31
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Amiodarone hydrochloride
T149619774-82-4
Amiodarone hydrochloride is an anti-anginal agent and a class III antiarrhythmic drug that inhibits potassium channels (including wild-type hERG channels and their tail currents, with an IC₅₀ of approximately 45 nM) as well as voltage-gated sodium channels. This leads to prolonged action potential duration in ventricular and atrial myocytes, resulting in reduced heart rate and vascular resistance. It activates ERK1/2 and p38 MAPK signaling pathways in fibroblasts, promoting cell proliferation and myofibroblast differentiation. Amiodarone hydrochloride is widely used in the study of supraventricular and ventricular arrhythmias and can also be used to establish pulmonary fibrosis animal models.
  • $36
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