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Colorectal cancer Modeling
Colorectal cancer (CRC) has shown a rising incidence in recent years, particularly among middle-aged and elderly populations. Its pathogenesis involves multiple genetic mutations, including APC, KRAS, and TP53. Common modeling approaches include AOM/DSS chemical induction, transgenic models, and patient-derived xenograft (PDX) models. These models play a vital role in studying the tumor immune microenvironment, inflammation-driven carcinogenesis, and the evaluation of anticancer therapies in colorectal cancer.
Azoxymethane
T7371925843-45-2
Azoxymethane (AOM) is a DNA damaging agent that induces cancer and can be used in mouse models of colorectal cancer.
- $83
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