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- Alangiaceae
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- Molecular Docking
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Colorectal cancer Modeling
Colorectal cancer (CRC) has shown a rising incidence in recent years, particularly among middle-aged and elderly populations. Its pathogenesis involves multiple genetic mutations, including APC, KRAS, and TP53. Common modeling approaches include AOM/DSS chemical induction, transgenic models, and patient-derived xenograft (PDX) models. These models play a vital role in studying the tumor immune microenvironment, inflammation-driven carcinogenesis, and the evaluation of anticancer therapies in colorectal cancer.
Azoxymethane
T7371925843-45-2
Azoxymethane (AOM) is a colon-specific carcinogen that induces DNA damage and forms DNA adducts, and is commonly used to establish mouse models of colorectal cancer.
- $169
Size
QTY
Dextran sulfate sodium salt (MW 36,000 - 50,000)
T13647L
Dextran sulfate sodium salt (MW 36,000–50,000) is a medium molecular weight polyanionic dextran derivative with strong intestinal epithelial permeability. It is the most commonly used agent for inducing inflammatory bowel disease (IBD) models, effectively inducing both acute and chronic colitis. Its mechanism may involve macrophage dysfunction and gut microbiota dysbiosis. Due to its colonic epithelial toxicity, long-term use can also induce colorectal cancer models.
- $30
Size
QTY
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