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Kidney Cancer Modeling
Renal cell carcinoma (RCC) is the most common type of malignant kidney tumor in adults and is closely associated with VHL gene mutations and dysregulation of the HIF signaling pathway. Modeling strategies include xenograft transplantation, genetically engineered mouse models, and CRISPR-based gene editing. These models are widely used to investigate the roles of metabolic dysregulation, angiogenesis, and immunotherapy in RCC.
Ferric nitrilotriacetate
T7865516448-54-7
Ferric nitrilotriacetate (Fe-NTA), an iron complex of nitriloacetic acid, is widely used to provoke oxidative stress (OS)-linked degenerative disorders. This compound has also been utilized in research to induce hyperglycemia, glycosuria, as well as renal and liver carcinogenesis [1].
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