Liver Cancer Modeling Products

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Cancer Modeling

Breast Cancer Modeling

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Colorectal cancer Modeling

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Gastric Cancer Modeling

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Kidney Cancer Modeling

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Liver Cancer Modeling

Liver Cancer Modeling

Liver cancer is one of the most prevalent and deadly malignancies worldwide, primarily including hepatocellular carcinoma (HCC) and cholangiocarcinoma. Its development is closely associated with chronic viral hepatitis, liver cirrhosis, and metabolic disorders. In animal model construction, liver cancer is commonly simulated through chemical induction, genetic engineering, or xenograft transplantation, providing critical support for drug screening and the investigation of targeted therapeutic mechanisms.

N-Nitrosodiethylamine

NDEA, Diethylnitrosamine

T3545555-18-5

N-Nitrosodiethylamine (NDEA) is a carcinogenic dialkylnitrosamine commonly found in water, tobacco smoke, cheddar cheese, pickled foods, fried foods, and various alcoholic beverages; it is associated with alterations in nucleases involved in DNA repair and replication, targets organs such as the nasal cavity, trachea, lungs, esophagus, and liver to induce tumors in animals, and is most commonly used to induce liver cancer models.

DNA/RNA Synthesis

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Chrysene

T14961218-01-9

Chrysene is a high-molecular-weight polycyclic aromatic hydrocarbon (PAH) with strong persistence and carcinogenicity. It is commonly used for establishing liver cancer models.

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Thioacetamide

TAA

T3536762-55-5

Thioacetamide (TAA) is an indirect hepatotoxin commonly used to induce experimental liver injury. It is metabolized by CYP2E1 into reactive metabolites that covalently bind to proteins and lipids, leading to oxidative stress and centrilobular necrosis, hepatocyte death, and M1/M2 macrophage-dominated inflammation. TAA is widely used to establish models of chronic liver fibrosis, hepatic encephalopathy, and liver cancer.

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N-Nitrosomorpholine

T4068459-89-2

N-Nitrosomorpholine is a light-sensitive nitrosamine with strong carcinogenicity in animals and is commonly used to induce liver cancer models.

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Dimethylnitrosamine

NDMA, DMN

T8255262-75-9

Dimethylnitrosamine (NDMA) is a potent hepatotoxin, carcinogen, and mutagen, and is commonly used to establish liver tumor models.

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Methyl yellow

Solvent Yellow 2, Dimethyl yellow

T8181160-11-7

Methyl yellow is a pH indicator dye that appears red in acidic environments and transitions to yellow above pH 4. Methyl yellow is also employed in animal studies to induce hepatic tumor formation, where its administration alters bile composition by reducing DHA levels and increasing bile volume, with DHA concentration strongly correlating with biliary output, making this compound useful in hepatotoxicity and bile-acid metabolism research.

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