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Gastric cancer is a common malignancy of the digestive tract, closely associated with Helicobacter pylori infection, genetic predisposition, and dietary factors. Model construction primarily relies on carcinogen induction (such as MNU and MNNG), transgenic techniques, and xenograft transplantation. Gastric cancer models are widely used to investigate tumor initiation mechanisms, tumor microenvironment remodeling, and the evaluation of novel targeted therapies.
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