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Gastric Cancer Modeling

Gastric cancer is a common malignancy of the digestive tract, closely associated with Helicobacter pylori infection, genetic predisposition, and dietary factors. Model construction primarily relies on carcinogen induction (such as MNU and MNNG), transgenic techniques, and xenograft transplantation. Gastric cancer models are widely used to investigate tumor initiation mechanisms, tumor microenvironment remodeling, and the evaluation of novel targeted therapies.

N-Nitroso-N-methylurea
T4169684-93-5
N-Nitroso-N-methylurea (NMU MNU NMH) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties; as a direct-acting alkylating agent, it interacts with DNA and targets multiple animal organs to induce various cancers and degenerative diseases, and is commonly used to induce disease models such as gastric cancer and breast cancer in mice.
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