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Pulmonary hypertension Modeling
Pulmonary Hypertension (PH) is a vascular disease characterized by persistently elevated pulmonary arterial pressure. Common modeling methods include single-dose SU5416 combined with hypoxia exposure, chronic hypoxia, and monocrotaline (MCT) induction. These models are widely used to investigate vascular remodeling, right heart failure, and the mechanisms of action of anti-PH therapies.
Monocrotaline
Cited
T2803315-22-0
Monocrotaline (Crotaline) is a pyrrolizidine alkaloid extracted from the seeds of the Crotalaria plant. Monocrotaline has certain cellular activity against HepG2 cells and can induce pulmonary hypertension in rodents.
- $41
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QTY
CitedSemaxinib
Cited
T2064204005-46-9
Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRβ, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.
- $44
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