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Pulmonary hypertension Modeling

Pulmonary Hypertension (PH) is a vascular disease characterized by persistently elevated pulmonary arterial pressure. Common modeling methods include single-dose SU5416 combined with hypoxia exposure, chronic hypoxia, and monocrotaline (MCT) induction. These models are widely used to investigate vascular remodeling, right heart failure, and the mechanisms of action of anti-PH therapies.

Monocrotaline
T2803315-22-0
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid extracted from the seeds of Crotalaria plants. It inhibits organic cation transporters OCT-1 and OCT-2, with IC50 values of 36.8 µM and 1.8 mM, respectively. Monocrotaline exhibits antitumor activity and shows certain cytotoxicity against liver cancer cells such as HepG2. It is also commonly used to induce pulmonary arterial hypertension models in rodents.
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Semaxinib
T2064204005-46-9
Semaxinib (SU5416) is a potent and selective VEGFR2 inhibitor (IC50: 1.23 μM), exhibiting a 20-fold greater selectivity for VEGFR2 over PDGFRβ, with no activity against InsR, EGFR, and FGFR. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of VEGFR2, potentially inhibiting VEGF-stimulated endothelial cell migration and proliferation, thereby reducing tumor microvasculature.
  • $44
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