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Chronic Obstructive Pulmonary Disease Modeling

Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung condition characterized by persistent airflow limitation. Common modeling methods include long-term cigarette smoke exposure and elastase instillation, which effectively replicate alveolar destruction, airway inflammation, and impaired lung function. These models are widely used to investigate disease pathogenesis and evaluate the efficacy of therapeutic interventions.

lipopolysaccharides
T11855
Lipopolysaccharides (LPS) derived from Escherichia coli 055:B5, are a unique component of the cell wall of Gram-negative bacteria. They are composed of three regions: lipid A, oligosaccharide core, and O-specific polysaccharide (O-antigen). Lipopolysaccharides help maintain the integrity of the cell outer membrane and protect bacteria from damage by bile salts and lipid antibiotics. Lipopolysaccharides are highly immunogenic antigens that can enhance immune responses and can be used to construct inflammatory models.
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Lipopolysaccharides, Escherichiacoli
T4107893572-42-0
Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) are derived from Escherichia coli O111:B4 and are a unique component of the cell wall of Gram-negative bacteria. They are composed of three regions: lipid A, oligosaccharide core, and O-specific polysaccharide (O-antigen). Lipopolysaccharides, Escherichiacoli help maintain the integrity of the cell outer membrane and protect bacteria from bile salts and lipid antibiotics.
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Elastase from porcine pancreas
T4049539445-21-1
Porcine pancreatic elastase is a serine protease composed of a single polypeptide chain with 240 amino acid residues. It has the ability to hydrolyze polypeptides and proteins, and can induce emphysema in hamsters.
  • $39
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