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ATR-IN-31
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Catalog No. T218521 Copy Product Info
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ATR-IN-31 is a selective ATR kinase inhibitor with an IC50 of 7 nM. It does not significantly inhibit ATM kinase activity and can suppress ATR kinase activity at the functional level. ATR-IN-31 is capable of inhibiting the viability of prostate cancer cells and is applicable for research related to prostate cancer.
ATR-IN-31
Cas No. 2954923-16-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ATR-IN-31 is a selective ATR kinase inhibitor with an IC50 of 7 nM. It does not significantly inhibit ATM kinase activity and can suppress ATR kinase activity at the functional level. ATR-IN-31 is capable of inhibiting the viability of prostate cancer cells and is applicable for research related to prostate cancer. |
| Targets & IC50 | ATR:7 nM |
| In vitro | ATR-IN-31 (compound M3) is a potent inhibitor of purified ATR kinase activity, with an IC50 of 7 nM, showing no significant inhibition on purified ATM kinase activity at IC50 >10000 nM. It effectively inhibits purified DNA-PK kinase activity with an IC50 of 179.6 nM. Additionally, ATR-IN-31 (compound M3) (0-50 μM; 120 h) significantly suppresses the viability of 22Rv1 human prostate cancer cells, achieving an IC50 of 0.21 μM after 120 hours of treatment. In human liver microsomes, ATR-IN-31 (compound M3) (2.0 nM) exhibits high stability with a half-life of 154.32 minutes, while in mouse liver microsomes, it demonstrates moderate stability with a half-life of 67.77 minutes. |
| Molecular Weight | 467.53 |
| Formula | C25H25N9O |
| Cas No. | 2954923-16-9 |
| Smiles | N=1C=CC=C(C1)N2N=C(C(C3=CC(=NC4=C(C=NN43)C5=NNC=C5)N6CC7OC(C6)CC7)=C2C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: ATR-IN-31 in vitro | ATR-IN-31 formula | ATR-IN-31 molecular weight
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