RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.

Cat. No.	Product name	CAS No.	Purity
T24152	HTH-01-091	2000209-42-5	98%
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T63055	RIPK1-IN-9	2682889-57-0	98%
RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respect...
T9702	Eclitasertib	2125450-76-0	98%
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
T7397	GSK547	2226735-55-1	98%
GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
T15437	GSK3145095	1622849-43-7	98%
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
T11484	GSK2593074A	1337531-06-2	98%
GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
T6815	HS-1371	2158197-70-5	98%
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
T12731	RIPK1-IN-7	2300982-44-7	98%
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...
T37558	Necrostatin-5	337349-54-9	98%
Necrostatin-5 is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α wit...
T12493	PK68	2173556-69-7	98%
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
T12728	RIP2 Kinase Inhibitor 3	1398053-50-3	98%
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
T7795	RIPA-56	1956370-21-0	98%
RIPA-56 is an inhibitor of RIP1
T9095	Necrostatin-34	375835-43-1	98%
Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
T5401	GSK2983559 active metabolite	1423186-80-4	98%
GSK 2983559 (RIP2 kinase inhibitor 1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
T11492	GSK2983559 free acid	1579965-12-0	98%
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
T5054	GSK963	2049868-46-2	98%
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
T9072	Tuxobertinib	2414572-47-5	98%
BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
T7151	GSK2982772	1622848-92-3	98%
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T3537	GSK583	1346547-00-9	98%
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T8931L	ICCB-19 hydrochloride	1803605-68-6	98%
ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T24152

HTH-01-091

2000209-42-5

98%

HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...

T63055

RIPK1-IN-9

2682889-57-0

98%

RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respect...

T9702

Eclitasertib

2125450-76-0

98%

Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).

T7397

GSK547

2226735-55-1

98%

GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.

T15437

GSK3145095

1622849-43-7

98%

GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.

T11484

GSK2593074A

1337531-06-2

98%

GSK2593074A is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.

T6815

HS-1371

2158197-70-5

98%

HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.

T12731

RIPK1-IN-7

2300982-44-7

98%

RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...

T37558

Necrostatin-5

337349-54-9

98%

Necrostatin-5 is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α wit...

T12493

PK68

2173556-69-7

98%

PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...

T12728

RIP2 Kinase Inhibitor 3

1398053-50-3

98%

RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.

T7795

RIPA-56

1956370-21-0

98%

RIPA-56 is an inhibitor of RIP1

T9095

Necrostatin-34

375835-43-1

98%

Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.

T5401

GSK2983559 active metabolite

1423186-80-4

98%

GSK 2983559 (RIP2 kinase inhibitor 1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.

T11492

GSK2983559 free acid

1579965-12-0

98%

GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...

T5054

GSK963

2049868-46-2

98%

GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).

T9072

Tuxobertinib

2414572-47-5

98%

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...

T7151

GSK2982772

1622848-92-3

98%

GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.

T3537

GSK583

1346547-00-9

98%

GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).

T8931L

ICCB-19 hydrochloride

1803605-68-6

98%

ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...