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RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T61424 OD36 hydrochloride 2387510-88-3 99.85%
OD36 hydrochloride
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ...
T3997 WEHI-345 1354825-58-3
WEHI-345
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
T78597 RIPK2-IN-3 1290490-78-6 98%
RIPK2-IN-3
RIPK2-IN-3 (FCG806791773) is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with an IC50 value of 6.39 μM against recombinant truncated RIPK2. It is a...
T79041 RIP1 kinase inhibitor 4 2919836-00-1 98%
RIP1 kinase inhibitor 4
RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].
T79042 RIP1 kinase inhibitor 5 2428422-17-5 98%
RIP1 kinase inhibitor 5
RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) in suppres...
T79043 RIP1 kinase inhibitor 6 2428401-62-9 98%
RIP1 kinase inhibitor 6
RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1 ki...
T79044 RIP1 kinase inhibitor 7 2428401-23-2 98%
RIP1 kinase inhibitor 7
RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM. Addition...
T79352 RIPK2/3-IN-1 98%
RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3. Additionally, in a 14-TriLAN-G...
T81267 RIPK3-IN-4 2304617-58-9 98%
RIPK3-IN-4
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage. It alleviates acute kidney injury by atte...
T81268 RIPK1-IN-17 98%
RIPK1-IN-17
RIPK1/3-IN-1 (Compound 10) is a selective inhibitor of both RIPK1 and RIPK3, effectively preventing necroptosis by blocking the phosphorylation of RIPK1, RIPK3, ...
T81269 RIPK1-IN-16 2561431-77-2 98%
RIPK1-IN-16
RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo. It shields mi...
T73382 SZM-1209 2919801-86-6 98%
SZM-1209
SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necropto...
T73493 RI-962 2763831-53-2 98%
RI-962
RI-962 is a potent and selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 of 35.0 nM. It is utilized for the investigation ...
T73511 SZM679 98%
SZM679
SZM679 is an orally active, selective RIPK1 inhibitor displaying potent affinity with a dissociation constant (Kd) of 8.6 nM for RIPK1, while exhibiting minimal ...
T4074L GSK872 HCl(1346546-69-7 free base) 2703752-81-0 99.82%
GSK872 HCl(1346546-69-7 free base)
GSK872 HCl(1346546-69-7 free base) (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM...
T6852 GSK481 1622849-58-4 99.71%
GSK481
GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
T12730 RIPK1-IN-4 1481641-08-0 99.66%
RIPK1-IN-4
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
T2048 LY-364947 396129-53-6 99.65%
LY-364947
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
T11501 GSK840 2361146-30-5 99.48%
GSK840
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase act...
T79600 Zharp2-1 2772600-18-5 99.41%
Zharp2-1
Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-i...
OD36 hydrochloride
T61424
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ...
WEHI-345
T3997
WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
RIPK2-IN-3
T78597
RIPK2-IN-3 (FCG806791773) is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with an IC50 value of 6.39 μM against recombinant truncated RIPK2. It is a...
RIP1 kinase inhibitor 4
T79041
RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].
RIP1 kinase inhibitor 5
T79042
RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) in suppres...
RIP1 kinase inhibitor 6
T79043
RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1 ki...
RIP1 kinase inhibitor 7
T79044
RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM. Addition...
RIPK2/3-IN-1
T79352
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3. Additionally, in a 14-TriLAN-G...
RIPK3-IN-4
T81267
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage. It alleviates acute kidney injury by atte...
RIPK1-IN-17
T81268
RIPK1/3-IN-1 (Compound 10) is a selective inhibitor of both RIPK1 and RIPK3, effectively preventing necroptosis by blocking the phosphorylation of RIPK1, RIPK3, ...
RIPK1-IN-16
T81269
RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo. It shields mi...
SZM-1209
T73382
SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necropto...
RI-962
T73493
RI-962 is a potent and selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 of 35.0 nM. It is utilized for the investigation ...
SZM679
T73511
SZM679 is an orally active, selective RIPK1 inhibitor displaying potent affinity with a dissociation constant (Kd) of 8.6 nM for RIPK1, while exhibiting minimal ...
GSK872 HCl(1346546-69-7 free base)
T4074L
GSK872 HCl(1346546-69-7 free base) (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM...
GSK481
T6852
GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
RIPK1-IN-4
T12730
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
LY-364947
T2048
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
GSK840
T11501
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase act...
Zharp2-1
T79600
Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-i...
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TargetMol