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MALT

MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.
Cat. No. Product name CAS No. Purity Chemical Structure
T16132 MRE3008F20 252979-43-4 98%
MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T l...
T16077 MIR96-IN-1 1311982-88-3 98%
MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
T36670 JNJ-67856633 2230273-76-2 98%
JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases....
T9216 MLT-943 1832576-04-1 98%
MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].
T2350 MALT1 inhibitor MI-2 1047953-91-2 98%
MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
T16040 Mepazine 60-89-9 98%
Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine en...
MRE3008F20
T16132
MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T l...
MIR96-IN-1
T16077
MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
JNJ-67856633
T36670
JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases....
MLT-943
T9216
MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].
MALT1 inhibitor MI-2
T2350
MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
Mepazine
T16040
Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine en...