MALT

MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.

Cat. No.	Product name	CAS No.	Purity
T16132	MRE3008F20	252979-43-4	98%
MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T l...
T16077	MIR96-IN-1	1311982-88-3	98%
MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
T16040	Mepazine	60-89-9	98%
Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine en...
T36670	JNJ-67856633	2230273-76-2	98%
JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases....
T9216	MLT-943	1832576-04-1	99.82%
MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].
T2350	MALT1 inhibitor MI-2	1047953-91-2	99.87%
MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T16132

MRE3008F20

252979-43-4

98%

MRE3008F20 is a highly effective and selective antagonist of adenosine A3 receptor (AA3R). MRE3008F20 also inhibits agonist-induced cAMP elevation in resting T l...

T16077

MIR96-IN-1

1311982-88-3

98%

MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.

T16040

Mepazine

60-89-9

98%

Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine en...

T36670

JNJ-67856633

2230273-76-2

98%

JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases....

T9216

MLT-943

1832576-04-1

99.82%

MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].

T2350

MALT1 inhibitor MI-2

1047953-91-2

99.87%

MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.