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MALT

MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.

  • Mepazine
    T1604060-89-9In house
    Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.
    • $33
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  • MLT-748
    T161201832578-30-9
    MLT-748 is a MALT1 allosteric inhibitor that inhibits the growth of lung cancer cells. MLT-748 acts by blocking the protein hydrolyzing activity of MALT1.
    • $297
    In Stock
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  • MLT-943
    T92161832576-04-1
    MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].
    • $123
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  • MIR96-IN-1
    T160771311982-88-3
    MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.
    • $289
    Backorder
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  • MALT1 inhibitor MI-2
    T23501047953-91-2
    MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor.
    • $39
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  • JNJ-67856633
    T366702230273-76-2
    JNJ-67856633 is an orally active, first-in-class, potent, selective and allosteric inhibitor of MALT1 protease . JNJ-67856633 lead to tumor stasis in some cases.
    • $48
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