Histone Demethylase

Histone demethylase proteins have a variety of domains that serve different functions. These functions include binding to the histone (or sometimes the DNA on the nucleosome), recognizing the correct methylated amino acid substrate and catalyzing the reaction, and binding cofactors. Cofactors include: alpha-keto glutarate (JmjC-domain containing demethylases), CoREST (LSD), FAD, Fe (II) or NOG (N-oxalylglycine).

Cat. No.	Product name	CAS No.	Purity
T15650	KDM5A-IN-1	1905481-36-8	98%
T15650	KDM5A-IN-1 is a potent and orally bioavailable inhibitor of pan-histone lysine demethylases 5 (IC50s: 45 nM, 56 nM, and 55 nM for KDM5A, KDM5B, and KDM5C) and (E...
T11503	GSK 690 Hydrochloride	T11503	98%
T11503	GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a K d value of 9 nM and a biochemical IC 50 of 37 nM.
T11475	GSK-J1 lithium salt	T11475	98%
T11475	GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC 50 of 60 nM towards KDM6B.
T11755	KF 13218	127654-03-9	98%
T11755	KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.
T13052	S2101	1239262-36-2	98%
T13052	S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1)(IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s).
T13056	T-448 free base	1597426-52-2	98%
T13056	T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).
T10864	Corin	1808113-09-8	98%
T10864	Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
T11881	LSD1-IN-6	2035912-43-5	98%
T11881	LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-6 is a potent and reversible inhibitor of lysine-specific dem...
T7057	Methylstat	1310877-95-2	98%
T7057	Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of...
T17278	YUKA1	708991-09-7	98%
T17278	YUKA1 is a potent and cell-permeable Lysine demethylase 5A inhibitor (IC50: 2.66 μM) and less active on KDM5C (IC50, 7.12 μM). YUKA1 is inactive on KDM5B, KDM6A,...
T12701	(rel)-Tranylcypromine D5 hydrochloride	107077-98-5	98%
T12701	(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine hydrochloride is an irreversible, nonsel...
T13057	T-448	1597426-53-3	98%
T13057	T-448 is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).
T3677	GSK2879552	1401966-69-5	98%
T3677	GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential ant...
T13745	KF21213	155271-17-3	98%
T13745	KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.
T11758	KI696 isomer	1799974-69-8	98%
T11758	KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 isomer is the less active isomer of KI696 .
T11880	LSD1-IN-5	2035912-55-9	98%
T11880	LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 is a potent and reversible inhibitor of lysine-specific de...
T39389	KDM2B-IN-2	1965248-01-4	98%
T39389	KDM2B-IN-2 is a potent histone demethylase (kdm2b) inhibitor.
T16700	QC6352	1851373-36-8	98%
T16700	QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
T11756	Kgp-IN-1	2097865-36-4	98%
T11756	Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.
T22299	CPI-455 HCl	2095432-28-1	98%
T22299	CPI-455 is a specific KDM5 inhibitor with IC50 value of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K...