u87

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-60, Breast adenocarcinoma MCF-7, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-4, Neuroblastoma UKF-NB-3, and Glioblastoma U87 mg cell, respectively.

L-Kynurenine ((S)-Kynurenine) is an endogenous agonist of the tryptophan metabolite and the aromatic hydrocarbon receptor (AHR). L-Kynurenine can inhibit the proliferation of allogeneic T cells and increase the invasion of malignant U87 glioma cells into the collagen matrix.

5-Hydroxyflavone is a natural product

Compound 2, or 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide, is an ent-kaurene diterpenoid extracted from Rubescens rubescens. This compound exhibits cytotoxic activity against various cell lines, including EC-1, U87, A549, MCF-7, and HeLa, with IC50 values of 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, and 462.13 μM, respectively, as well as 180.09 μM against another unspecified line [1].

Mycothiazole is an inhibitor of mitochondrial electron transport chain (ETC) complex I. It exhibits cytotoxicity in cancer cells Huh7 (IC50 of 55.8 μM), U87, and MCF7. In Huh7 cells, Mycothiazole induces apoptosis (apoptosis). Additionally, Mycothiazole extends the lifespan of C. elegans by modulating transcription factors ATFS-1 and HSF1, which are associated with the unfolded protein response (UPR) and heat shock response (HSR).

Ecdysoside B (compound 6b) is a pregnane glycoside isolated from the plant Ecdysanthera rosea. This compound and its derivatives and isomers exhibit anticancer, immunosuppressive, and anti-inflammatory activities. Ecdysoside B demonstrates cytotoxicity against various human tumor cell lines, including PANC-1 (human pancreatic cancer cells), A375 (human melanoma cells), and U87 (glioblastoma U87 cells). It is a valuable compound for research in cancer, immunomodulation, and anti-inflammation.