tetramer

Aurothiomalate tetramer sodium, a tetrameric form of Aurothiomalate sodium, functions as an anti-arthritis gold agent. It also acts as a potent and selective inhibitor of the oncogenic PKCι signaling pathway.

RUNX1 ETO tetramerization-IN-1 is a small-molecule inhibitor targeting NHR2 of RUNX1 ETO, effectively inhibiting tetramerization with an EC50 value of 0.25 μM. This compound restores gene expression down-regulated by RUNX1 ETO and demonstrates anti-leukemic activity by inhibiting proliferation of RUNX1 ETO-dependent SKNO-1 cells and reducing tumor growth in a mouse model [1] [2] [3].

Vitisin A ((+)-Vitisin A) is a resveratrol tetramer that can be isolated from the roots of Vitis vinifera and possesses antioxidant, anticancer, antiapoptotic, neuroprotective, and anti-inflammatory activities.It ameliorates the impaired learning and memory functions of scopolamine-induced amnesia in ICR mice, and can be used in the study of degenerative diseases.

Pulcherosine, a compound formed through the oxidative coupling of isodityrosine and tyrosine, features a biphenyl linkage that creates a 2,2'-dihydroxy-3-phenoxybiphenyl aromatic core. It functions as an intermediate in the transformation of isodityrosine into the tetramer di-isodityrosine. Additionally, Pulcherosine contributes to the formation of inter-polypeptide cross-links and or extensive intra-polypeptide loops.

Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure.

TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients. It inhibits oxidative phosphorylation (OXPHOS) and shifts cellular metabolism toward glycolysis. Additionally, TRAP1-IN-2 compromises the stability of the TRAP1 tetramer and disrupts the mitochondrial membrane potential [1].

GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https: www.medkoo.com page naming).

Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) stained splenic CD8+ T cells from NOD or 8.3-TCRαβ transgenic NOD mice.

ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor.

BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inte

Streptavidin is a protein tetramer purified from bacteria with a very high affinity for biotin and is commonly used for the purification or detection of various biomolecules. Streptavidin is immunologically active, inhibiting IL-2 synthesis and CD25 expression in T cells.