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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8550 | NDMC101 | Others , NF-κB , Proteasome | |
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity. | |||
TN4893 | Rapanone | 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone,2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione | Apoptosis , Phospholipase , Antibacterial , Parasite |
Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2. | |||
T73425 | CFT8634 | ||
CFT8634 is a degrader targeting BRD9. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors. | |||
T3762 | Hyaluronic acid | Hyaluronate,hyaluronan | Others , Endogenous Metabolite |
Hyaluronic acid (hyaluronan) is a glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial ... | |||
T4282 | S-methyl-KE-298 | MMP , Drug Metabolite | |
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. | |||
T31751 | Fce 21258 | Ddh-carbo pgl2 | |
Fce 21258 is used to stimulate the adenylate cyclase of synovial fluid macrophages. | |||
T19771 | SXT1596 | NSC-65667,SXT-1596,NSC 65667,SXT 1596,NSC65667 | |
SXT1596 is a novel SS18-SSX/TLE1 interaction inhibitor. SXT1596 reduces cell viability and reactivates EGR1 expression in synovial sarcoma. | |||
T82239 | HAP-1 | ||
HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin. When fused with the antimicrobial peptide (KLAK)2, HAP-1 form... | |||
T35480 | DBRD9-A | dBRD9-A | |
Potent BRD9 degrader. Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xeno... | |||
T70230 | FPTI | ||
FPTI is an inhibitor against SYT-SSX1 fusion protein in synovial sarcoma which down-regulates SYT-SSX1 and modulates its downstream target genes. | |||
T76989 | Tabituximab barzuxetan | ||
Tabituximab barzuxetan (OTSA101-DTPA-90Y) is a radioimmunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101) , and labeled with Yttrium 90. Tabituximab barzuxetan shows antineoplastic acti... | |||
T70834 | BE-16627B | ||
BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 da... | |||
T68344 | AGG-523 | ||
AGG-523 is an aggrecanase specific inhibitor that has been shown to attenuate increases in synovial fluid ARG-aggrecan levels following surgically-induced joint instability in the rat MT model. Pharmacologic inhibition o... | |||
T21893 | Luffariellolide | ||
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 ( HSF-PLA2 ) (IC 50 =5 μM). PMA-induced ear edema was effectively inhibited by luffariellolide (ED 50 =50 μg/ear) [1]. | |||
TN4505 | Masticadienolic acid | Others | |
Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid... | |||
T71525 | AB05831 | ||
AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis... | |||
T38143 | Elaidamide | ||
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu... | |||
T60979 | Oxaprozin potassium | ||
Oxaprozin potassium is an orally active and potent inhibitor of COX, with IC 50 values of 2.2 μM and 36 μM for human platelet COX-1 and for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium in... | |||
T68321 | AS1940477 | ||
AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blo... | |||
T37606 | Resolvin D5 | 7(S),17(S)-diHDHA | |
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory respons... |