rnase

Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.

DEPC (Diethyl pyrocarbonate) is a potent and irreversible RNase inhibitor containing histidine residues.DEPC can be used to prevent RNA enzyme degradation by modifying histidine residues with carboxylation resulting in enzyme inactivation. DEPC showed inhibitory effect on the central chemical sensitivity of rabbits. DEPC modified His, Tyr, Ser and Thr residues.

RNAse L RIBOTAC (compound C64) is an RNA-degrading chimera that binds to a four-way RNA helix called SL5 located in the 5’ UTR of the SARS-CoV-2 RNA genome, thereby inhibiting viral replication in pulmonary epithelial cancer cells.

RNase L ligand 1 (Compound F1-COOH) serves as a ligand for RNase L and is utilized in the synthesis of F1-RIBOTAC.

RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.

RNase L-IN-1 (compound 17a) functions as an inhibitor of RNase L (Ribonuclease L), an enzyme responsible for RNA degradation to inhibit viral replication and mediate innate immune responses and inflammation [1].

Thermally stable RNase H efficiently degrades the RNA strand of DNA-RNA hybrids without affecting the DNA or non-hybridized RNA strands, significantly enhancing sensitivity and selectivity. Its activity peaks at 65°C and remains active at temperatures as high as 95°C.

DNase I (RNase & Protease free) (EC 3.1.21.1) is an enzyme that degrades DNA and plays a crucial role in the breakdown of extracellular DNA. It is vital for limiting inflammatory responses and maintaining homeostasis. Exogenous DNase I has beneficial effects in inflammatory diseases and cancer. It is of molecular biology grade, purified by chromatography to remove RNase and protease contaminants.

RNase L-IN-2 is an activator of RNase L with EC50 of 22 uM; shows broad-spectrum antiviral activity against diverse types of RNA viruses, including the human pathogen human parainfluenza virus type 3, with no cytotoxic at the effective concentrations.

RNase B, Bovine Pancreas, is the N-glycosylated form of bovine pancreatic ribonuclease, structurally analogous to RNase A. It assists in polypeptide chain folding and functions similarly to a molecular chaperone.

RNase A, Bovine Pancreas (Ribonuclease A) (DNase & Protease Free) is a ribonuclease and a widely used endonuclease that functions by specifically hydrolyzing cytosine or uracil residues in RNA. It is commonly employed in cell cycle analysis experiments.

RNase H2 is the primary source of RNase H activity in mammalian and human cells, crucial for maintaining genomic integrity. It is involved in the removal of ribonucleotides from yeast and mouse genomic DNA, a process essential for embryonic development.

RNase A (10mg/mL, DNase free) is a ribonuclease used to catalyze RNA degradation and lacks DNase activity. It is commonly utilized in cell cycle analysis experiments.

D-F07 belongs to fluorescent dye-class tricyclic chromone compounds and is an IRE1 inhibitor (prodrug form containing an aldehyde-masked group) with cell permeability. This compound induces tumor cell apoptosis through inhibition of the IRE1/XBP1 pathway, exhibiting significant antitumor activity, and is suitable for related mechanism research and antitumor drug development.

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α), effectively inhibiting both its RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).

B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells., an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells., an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells.

Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.

4μ8C (IRE1 Inhibitor III) is a highly selective and potent inhibitor of IRE1α ribonuclease (RNase) activity (IC₅₀ ≈ 6–10 μM). By forming a covalent bond with the RNase active site of IRE1α, 4μ8C specifically inhibits its ribonuclease activity, thereby blocking the splicing of XBP1 mRNA. 4μ8C can be used in research on endoplasmic reticulum stress, the unfolded protein response, immune regulation, and tumor and metabolic diseases.

Ribonuclease A (RNase A) is a potent endonuclease that removes RNA during dna and protein preparation.

Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.

HIV-1 integrase inhibitor 9 (compound 8a) is a potent inhibitor of HIV-1 RNase H (IC50: 12.3 μM) with antiviral effects.

6'-O-Galloylsalidroside has antiviral activity and inhibits HIV.