r form

Bay 65-1942 (R form) is the less active enantiomer of Bay 65-1942, a selective and ATP-competitive IKKβ inhibitor.

EMD638683 is a highly selective SGK1 inhibitor with an IC50 of 3 μM. EMD638683 (R-Form) is the R-form of this compound.

2'-O-(3-Methylbutanoyl)-Aviprin (R-form) is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson's disease.

Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is no longer in common use because of the occurrence of rare drug side-effects including hepatitis and fever.

Arformoterol Tartrate ((R,R)-Formoterol tartrate) is the tartrate salt of arformoterol. Arformoterol is a long-acting beta-2 adrenergic agonist with bronchodilator activity[2].

Pactimibe is a ACAT inhibitor. It has anti-atherosclerotic activity.

Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor, acting on ACAT1 (IC50: 4.9 μM) and ACAT2 (IC50: 3.0 μM). It inhibits oleoyl-CoA non-competitively (Ki: 5.6 μM) and significantly inhibits cholesterol ester formation (IC50: 6.7 μM). Pactimibe sulfate reduces plasma cholesterol activity and has anti-atherogenic potential.

Minnelide is an effective therapy against pancreatic cancer. Minnelide Inhibits Androgen Dependent, Castration Resistant Prostate Cancer Growth by Decreasing Expression of Androgen Receptor Full Length and Splice Variants. Minnelide reduced tumor volume in multiple models of pancreatic cancer. Minnelide was a more effective drug against pancreatic cancer models. It effectively reduced tumor burden and tumor related morbidity in different unique but complementary mouse models. It reduced metastatic spread and increased survival in the different models as well.

Arformoterol Tartrate (Standard) is the standard substance of Arformoterol Tartrate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Arformoterol Tartrate ((R,R)-Formoterol tartrate) is the tartrate salt of arformoterol. Arformoterol is a long-acting beta-2 adrenergic agonist with bronchodilator activity.

(Rac)-Apremilast-D5 is a deuterium-labeled version of the enantiomer (R)-Apremilast, also known as (R)-CC-10004, which itself is one specific form of Apremilast.

SAR405 (R enantiomer) is the less active form of SAR405, an inhibitor of PIK3C3/Vps34.

(R)-Pantetheine (Pantetheine) is the biologically active form of VB5 (pantothenic acid), which occurs in nature in various forms of Pantetheine-containing ligands (PCL). (R)-Pantetheine increases platelet cell membrane fluidity and inhibits platelet aggregation.

(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized conjugate for E3 ligase ligand-linker applications, combining the VH032 VHL-based ligand with a linker for PROTAC development. VH-032 is a selective and potent VHL/HIF-1α interaction inhibitor with a dissociation constant (Kd) of 185 nM, offering potential in anemia and ischemic diseases research[1].

(R,R)-(+)-Hydrobenzoin is an o-diol compound with chiral configuration, which belongs to endogenous metabolites and is often used as chiral ligand or chiral auxiliary reagent in asymmetric synthesis to induce stereoselectivity. (R,R)-(+)-Hydrobenzoin rigid diphenyl glycol skeleton can form complexes with metal ions, which has important application value in catalysis and chiral recognition research.

(R,S,S)-VH032-Me is a ligand for the E3 ubiquitin ligase. It can connect with a target protein ligand via a linker to form dTAGV-1-NEG. This PROTAC can induce the ubiquitination and subsequent degradation of oncogenic proteins.

(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).

β2AR agonist 2 (compound 8a) is an agonist of the β2-adrenergic receptor (β2AR). It is a saturated azacyclic compound featuring a 4- to 7-membered heterocycle. The compound has a chiral structure in the -R form by incorporating a carbon with a requisite hydroxyl group, which significantly stimulates glucose uptake in skeletal muscle cells, thereby enhancing cellular glucose uptake (GU). β2AR agonist 2 is applicable in the study of type 2 diabetes (T2D).

(S,R,S)-AHPC-C7-aminedihydrochloride is the dihydrochloride salt form of (S,R,S)-AHPC-C7-amine. The compound (S,R,S)-AHPC-C7-amine is a synthetic E3 ligase ligand-linker (E3ligaseligand-linker conjugate) that includes a VHL ligand based on VH032 and one linker. It is utilized for synthesizing PROTAC degraders targeting ERRα.

(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH is a conjugate of the VHL ligand of the E3 ubiquitin ligase VH032 and a linker. This linker component of (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH can be further conjugated with a target protein ligand (such as BCR-ABL1) to form a PROTAC molecule.

(R,S)-Cotinine-D3 N-Oxide is the deuterated form of (R,S)-Cotinine N-Oxide.

SM1-71-R is a reversible analogue of SM1-71. Lacking the acrylamide warhead, SM1-71-R is unable to form covalent bonds with kinases, making it suitable as a control compound for SM1-71.

(R)-KRAS G12D inhibitor 28 hydrochloride dihydrate is the dihydrate hydrochloride salt form of (R)-KRAS G12D inhibitor 28. KRAS G12D inhibitor 28 (Compound 1) acts as an inhibitor of the KRAS G12D protein and is utilized in cancer research.

(R,S)-STT3A/B-IN-1 (compound 32) is the racemic form of STT3A/B-IN-1 and functions as an STT3A/B inhibitor. It suppresses N-glycosylation (N-Glycosylation) and has potential applications in research related to viral diseases, cancer, and neurodegenerative disorders.