neutrophil elastase

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.

ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).

Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.

3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor

BOS-318 is a Furin inhibitor with IC50 of 1.9 nM, and has the characteristics of slow dissociation, high selectivity, and cell permeability.

Neutrophilelastase inhibitor 5 (Compound 29) acts as a dual inhibitor of HNE (human neutrophil elastase) and protease 3 (PR3), with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophilelastase inhibitor 5 is applicable for research in neutrophil inflammatory diseases.

Neutrophilelastase inhibitor6 (compound 113) is an irreversible phosphonate-based inhibitor of human neutrophil elastase (neutrophilelastase).

Neutrophil elastase-IN-7 (Compound 12) is a potent inhibitor of human neutrophil elastase (HNE) with an IC50 of 0.54 μM. It also exhibits significant inhibitory activity against various coagulation proteins, with IC50 values of 8.2 μM for thrombin, 12.7 μM for FXa, 1.2 μM for FXIa, and 5.7 μM for FXIIIa. Neutrophil elastase-IN-7 is applicable in the study of inflammation, innate immune responses, and tissue remodeling.

Neutrophil elastase inhibitor 4 (compound 4f) is a competitive inhibitor of human neutrophil elastase (HNE) with an IC50 of 42.30 nM and a Ki of 8.04 nM. It induces apoptosis in T47D cells and inhibits the proliferation of T47D, RPMI 8226, A549, and HSF cells with respective IC50 values of 21.25, 34.17, 29.93, and 99.11 nM [1].

NeutrophilElastase(NEG) serves as a biomaterial or organic compound applicable in life sciences research.

Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one targets the Neutrophil elastase (human).

AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.

FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef

Sivelestat sodium (EI 546 sodium) is a highly efficient inhibitor of human neutrophil elastase, improving sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway. It can be used in acute lung injury/acute respiratory distress syndrome research.

Alvelestat can inhibit neutrophil elastase (NE), which acts an important role in NET formation.

Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9, thereby decreasing inflammatory mediators during simulated cardiopulmonary bypass.

2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one is an human neutrophil elastase inhibitor.

BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).

GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase, displaying higher affinity for human elastase (Ki = 0.0168 nM) compared to rat (Ki = 3 nM), mouse (Ki = 1.8 nM), and rabbit (Ki = 58 nM) elastases [2]. It reduces myocardial infarct size following ischemia-reperfusion injury [1] and has potential for treating chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis, and various inflammatory diseases.

AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the pancreas.AZD8309 can be used to study a range of inflammatory diseases.

JNJ-10311795 (RWJ-355871) is a potent dual inhibitor of neutrophil elastase (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM) with significant anti-inflammatory activity, useful for studying pneumonia.