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Results for "

mmp 13

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    47
    TargetMol | Inhibitors_Agonists
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TargetMolTargetMolCompare
MMP-13 Protein, Human, Recombinant (His & SUMO)
MMP13, Matrix metalloproteinase-13 (MMP-13), Collagenase 3
TMPH-01124
Expression system: E. coli
Length: 104-471, Full Length of Mature Protein
Activity: Not Tested
  • Inquiry Price
20 days
Size
QTY
Buffer-exchangeable
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MMP-13 Protein, Mouse, Recombinant (His)
Mmp13, Matrix metalloproteinase-13 (MMP-13), Collagenase 3
TMPH-02594
Expression system: E. coli
Length: 105-472, Full Length of Mature Protein
Activity: Not Tested
  • Inquiry Price
20 days
Size
QTY
Buffer-exchangeable
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TIMP3 Protein, Human, Recombinant (His)
Tissue inhibitor of metalloproteinases 3 (TIMP-3), TIMP3, Protein MIG-5, Metalloproteinase inhibitor 3
TMPH-01665
Expression system: E. coli
Length: 30-208, Partial
Activity: Not Tested
  • Inquiry Price
20 days
Size
QTY
Buffer-exchangeable
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MMP-1 Protein, Human, Recombinant (His)
matrix metallopeptidase 1, CLGN, CLG
TMPY-00886
MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defenses. Dysregulation of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis, and cancer. Tumour metastasis is a multistep process involving the dissemination of tumor cells from the primary tumor to secondary at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and or metastases. MMP-1 cleaves collagens of types I, II, and III at one site in the helical domain. It also cleaves collagens of types VII and X. In case of HIV infection, MMP1 interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
  • Inquiry Price
7-10 days
Size
QTY
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MMP-12 Protein, Human, Recombinant (catalytic domain)
MMP-12, MME, ME, matrix metallopeptidase 12, HME
TMPY-02869
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, MMP12, and MMP-12, is a secreted protein that belongs to the peptidase M1A family. MMP12 is a macrophage-secreted elastase that is highly induced in the liver and lung in response to S. mansoni eggs and contains four hemopexin-like domains. MMP12 is a proteolytic enzyme responsible for the cleavage of plasminogen to angiotensin, which has an angiostatic effect. It may be involved in tissue injury and remodeling and has significant elastolytic activity. It may be related to prognosis in breast cancer patients. MMP12 promotes fibrosis by limiting the expression of specific ECM-degrading MMPs. Like MMP12, MMP13 expression is highly dependent on IL-13 and type I I-IL-4 receptor signaling. MMP12 is a potent proinflammatory and oncogenic molecule. MMP12 up-regulation plays a critical role in emphysema to lung cancer transition that is facilitated by inflammation.
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer