mast cells

Expression system: E. coli
Length: 29-151, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-144, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 31-275, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 31-275, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 34-150, Extracellular Domain
Activity: Not Tested

Expression system: E. coli
Length: 22-246, Partial
Activity: Not Tested

Expression system: E. coli
Length: 35-267, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-74, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 19-181, Extracellular Domain
Activity: Not Tested

Expression system: E. coli
Length: 2-262, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 21-260, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-761, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 29-273, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 20-134, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 29-159, Full Length of Mature Protein
Activity: BLI、ELISA

Expression system: HEK293 Cells
Length: 27-166, Full Length of Mature Protein
Activity: Cells Activity

Expression system: HEK293 Cells
Length: 18-178, Partial
Activity: Not Tested

T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.

Expression system: HEK293 Cells
Length: 27-266, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 20-203, Partial
Activity: Not Tested

Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. In addition, Serpin B6 may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.

Expression system: HEK293 Cells
Length: 48-388, Partial
Activity: Not Tested

Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation

Expression system: HEK293 Cells
Length: 31-370, Extracellular Domain
Activity: BLI