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Cat No. | Product Name | Synonyms | Targets |
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T16777 | ROC-325 | Apoptosis , Autophagy | |
ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity. | |||
T1885 | Siramesine hydrochloride | Lu 28-179 hydrochloride | Ferroptosis , Sigma receptor , lysosomal autophagy |
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo. | |||
T4620 | Siramesine | Lu 28-179 | Sigma receptor |
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram... | |||
T60036 | ML-SA5 | Autophagy | |
ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes. | |||
T77553 | MHI-148 | IR-808 | |
MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.MHI-148 is taken up and accumulates in the lysosomes and mitochondria of tumor cells but is not ... | |||
T77945 | TriGalNAc CBz | LYTACs | |
TriGalNAc CBz is a GalNAc derivative. As an ASGPR ligand, tri-GalNAc targets lysosomes in mRNA drug delivery and LYTAC studies.L-DABA hydrobromide. | |||
T1908 | MHY1485 | mTOR , Autophagy | |
MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3II protein and enlarged autophagosomes. | |||
T37885 | 1-Dodecylimidazole | Antifungal | |
1-Dodecylimidazole (N-Dodecylimidazole) is a cytotoxic agent and a lysosomotropic detergent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and... | |||
T21992 | Vacuolin-1 | PI3K , Autophagy | |
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits ... | |||
T33674 | NIM-7 | NIM7 | |
NIM-7 is a fluorescent probe, allowing lipid droplets and lysosomes to be labelled simultaneously and with high specificity, being visualized readily through yellow and red fluorescence, using different excitation and de... | |||
T35922 | NAADP (sodium salt) | ||
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then... | |||
T39855 | LysoTracker Red | LysoTracker Red DND-99 | |
LysoTracker Red (LysoTracker Red DND-99) is a paraformaldehyde fixable probe that concentrates into acidic compartments of cells and tissues. LysoTracker Red is an indicator of cell death in a manner similar to other st... | |||
T35930 | Ganglioside GM2 Mixture (sodium salt) | ||
Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse mo... | |||
T78371 | Ac2-26 ammonium | ||
Ac2-26 ammonium, an N-terminal peptide of annexin 1, exhibits anti-inflammatory properties, reduces IKKβ protein levels in lysosomes via chaperone-mediated autophagy (CMA), improves lung ischemia-reperfusion injury outco... | |||
T79556 | NDBM | Autophagy | |
NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and ... | |||
T36370 | 4-Methylumbelliferyl-α-L-Iduronide (free acid) | ||
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and hepa... | |||
T77186 | Zilovertamab vedotin | ||
Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor... | |||
T73550 | CUR5g | ||
CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-d... | |||
T77131 | Clervonafusp alfa | ||
Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosid... | |||
T77876 | Py-MAA-Val-Cit-PAB-MMAE | AAJ8D6-PY-Val-Cit-MMAE | |
Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) serves as an ADC linker for Zapadcine-3a, a broad-spectrum anti-TRAILR2 ADC with antineoplastic properties. By targeting TRAILR2, Zapadcine-3a is internalized into the lys... | |||
T36805 | TPC2-A1-N | TPC2-A1-N | |
TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through i... | |||
T36806 | TPC2-A1-P | TPC2-A1-P | |
TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher poten... |
Cat No. | Product Name | Synonyms | Targets |
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T6740 | Bafilomycin A1 | Apoptosis , Proton pump , Antibacterial , Antibiotic , Autophagy | |
Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autopha... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00672 | Azurocidin/CAP37 Protein, Human, Recombinant (His) | Human | HEK293 |
Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil... | |||
TMPY-00989 | LDLR Protein, Human, Recombinant (His) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-02450 | Cathepsin D Protein, Human, Recombinant (His) | Human | HEK293 |
Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly... | |||
TMPY-01727 | GLA/alpha-Galactosidase A Protein, Human, Recombinant (His) | Human | HEK293 |
Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap... | |||
TMPY-00735 | Cathepsin S Protein, Human, Recombinant (His) | Human | HEK293 |
Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS... | |||
TMPY-02751 | Cathepsin S Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS... | |||
TMPY-00731 | Cathepsin B Protein, Human, Recombinant (His) | Human | HEK293 |
Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas... | |||
TMPY-02737 | DPP2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity,... | |||
TMPY-00777 | DPP2 Protein, Human, Recombinant (His) | Human | HEK293 |
DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity,... | |||
TMPH-01540 | Intelectin-1/ITLN1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to t... | |||
TMPH-02542 | DEFB19 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence pla... | |||
TMPH-02096 | PPP2CA Protein, Human, Recombinant (His & Myc) | Human | E. coli |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou... | |||
TMPY-00670 | ARSA Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major ... | |||
TMPY-00669 | ARSA Protein, Human, Recombinant (His) | Human | HEK293 |
Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major ... | |||
TMPY-00475 | PPT1 Protein, Human, Recombinant (His) | Human | HEK293 |
Mutations in the depalmitoylating enzyme gene, PPT1, cause the infantile form of Neuronal Ceroid Lipofuscinosis (NCL), an early onset neurodegenerative disease. Mutations in palmitoyl protein thioesterase-1 (PPT1) have b... | |||
TMPY-04055 | PPT1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Mutations in the depalmitoylating enzyme gene, PPT1, cause the infantile form of Neuronal Ceroid Lipofuscinosis (NCL), an early onset neurodegenerative disease. Mutations in palmitoyl protein thioesterase-1 (PPT1) have b... | |||
TMPY-04990 | NPC2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. ... | |||
TMPY-01114 | NPC2 Protein, Human, Recombinant (His) | Human | HEK293 |
Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. ... | |||
TMPY-00131 | Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 |
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pi... | |||
TMPJ-00497 | CTSB Protein, Human, Recombinant (His) | Human | Human Cells |
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, bot... | |||
TMPY-00264 | NPC2 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. ... | |||
TMPJ-00264 | LAMP1 Protein, Human, Recombinant (hFc) | Human | Human Cells |
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysoso... | |||
TMPY-05768 | LIMPII/SR-B2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all ... | |||
TMPY-02885 | CD1B Protein, Human, Recombinant (hFc) | Human | HEK293 |
CD1B contains 1 Ig-like (immunoglobulin-like) domain and belongs to the CD1 family. CD1 family members are transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) protein... | |||
TMPY-04621 | OSTM1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 associat... | |||
TMPH-02067 | SLURP1 Protein, Human, Recombinant (His) | Human | E. coli |
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistribut... | |||
TMPY-05499 | LDLR Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-03033 | CD68 Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Macrosialin, also known as CD68 and Gp11, is a single-pass type I membrane protein which belongs to theLAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocyt... | |||
TMPY-03094 | CD68 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Macrosialin, also known as CD68 and Gp11, is a single-pass type I membrane protein which belongs to theLAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocyt... | |||
TMPY-01194 | OSTM1 Protein, Human, Recombinant (His) | Human | HEK293 |
Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 associat... | |||
TMPY-01014 | LDLR Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-05323 | LDLR Protein, Human, Recombinant (mFc) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-01024 | LIMPII/SR-B2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all ... | |||
TMPY-01434 | LIMPII/SR-B2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all ... | |||
TMPJ-00299 | LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Lysosome membrane protein II (LIMPII),also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far e... | |||
TMPY-02252 | LAMTOR2 Protein, Human, Recombinant (His) | Human | E. coli |
Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-... | |||
TMPY-05486 | CD68 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Macrosialin, also known as CD68 and Gp11, is a single-pass type I membrane protein which belongs to theLAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocyt... | |||
TMPY-05210 | CD68 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Macrosialin, also known as CD68 and Gp11, is a single-pass type I membrane protein which belongs to theLAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocyt... | |||
TMPY-00733 | Cathepsin D Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly... | |||
TMPY-05809 | LDLR Protein, Human, Recombinant (193D/A, His) | Human | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPY-02972 | CD68 Protein, Human, Recombinant (aa 1-319, His) | Human | Baculovirus-Insect Cells |
Macrosialin, also known as CD68 and Gp11, is a single-pass type I membrane protein which belongs to theLAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocyt... | |||
TMPY-05348 | LDLR Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 |
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i... | |||
TMPH-01495 | HLA-DQB1 Protein, Human, Recombinant (His) | Human | E. coli |
Serine protease that cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4: known substrates are SREBF1/SREBP1, SREBF2/SREBP2, BDNF, GNPTAB, ATF6 and ATF6B. Cleaves substrates after Arg-... | |||
TMPY-00732 | Cathepsin C Protein, Human, Recombinant (His) | Human | HEK293 |
Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also kno... | |||
TMPY-02857 | GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap... | |||
TMPJ-00837 | LAMP1 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature mouse LAMP1 consists of a 346 amino acid (aa) intral... | |||
TMPJ-00298 | CD36 Protein, Human, Recombinant (aa 27-432, His) | Human | Human Cells |
Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlie... | |||
TMPY-03986 | PIST Protein, Human, Recombinant (His) | Human | E. coli |
GOPC, also known as PIST, interacts specifically with TC1 (a Rho-family small GTPase)] as a binding partner for Rhotekin. Rhotekin associates with PIST in vitro and both polarized and non-polarized MDCK (Madin-Darby cani... | |||
TMPH-03043 | PIA Protein, MenB, Recombinant (His) | MenB | E. coli |
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the m... | |||
TMPY-02063 | Alpha-2-macroglobulin Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
alpha-2-macroglobulin, also known as α2-macroglobulin (α2M and A2M), is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protei... | |||
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Cat No. | Product Name | ||
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L3200 | Autophagy Compound Library | 1248 compounds | |
A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; |