latent

Primaquine diphosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts).

CEF19, Epstein-Barr Virus latent NA-3A (458-466), is a peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain).

Monomethylaniline is used predominantly as a key synthetic intermediate in the industrial manufacture of dyes, agrochemicals, and other organic products; Monomethylaniline also serves specialized functions as a latent and coupling solvent, as a component in octane boosters for gasoline, Monomethylaniline it can also be used in the development of advanced materials like electrodeposited coatings.

BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50:  1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1.5 nM) [2]. BRD-6929 potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV

ELQ316 is an antiparasitic compound. In mouse models of acute and latent toxoplasmosis, ELQ316 demonstrates high efficacy, with its in vitro IC50 values at the picomolar level.

Lipid C2 is an ionizable cationic lipid utilized in the formation of lipid nanoparticles (LNP) for the delivery of mRNA in vivo. LNPs containing Lipid C2 and encapsulating mRNA reporter genes specifically accumulate in the liver and spleen of mice, while avoiding the heart, lungs, and kidneys. Additionally, LNPs with Lipid C2 that encapsulate mRNA encoding Epstein-Barr virus (EBV) protein Latent Membrane Protein 2 (LMP-2), when combined with anti-programmed cell death protein 1 (PD-1) antibodies, have been shown to reduce tumor size, reverse T cell exhaustion, increase the percentage of CD3+CD8+ central T cells and CD3+CD8+ effector memory T cells in the spleen, and decrease the percentage of CD3+T cells expressing Pd-1 in a CT26 mouse model of EBV-infected colon cancer.

HDAC3-IN-T326 is a potent and selective HDAC3 inhibitor that acts by increasing NF-κB acetylation and activating HIV gene expression in latent HIV-infected cells.

Ingenol 3-Hexanoate is a novel potent reactivator of latent HIV-1.

MDG486, an inhibitor of BAF, works by activating latent HIV-1.

SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.

17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection.

1. Ingenol ((-)-Ingenol) mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from Ingenol esters may be an innovative approach to develop new lead compounds to reactivate latent HIV. 3. Ingenol is a weak PKC activator and possesses important anticancer activity.

HIV-1 inhibitor-37 (Compound 83) is a potent HIV-1 inhibitor with significant potential as an innovative latent HIV-1 reactivating agent [1].

Dibrospidium Free Base is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correlate with spirobromine antitumor activity. Spirobromin is superior to prospidin by the power of the anti-inflammatory effect. Spyrobromin can diminish the latent period of the development of tumours in the experimental rats at intraperitoneal administration. At intragastric administration of the drug no decrease was noted in the latent period and no increase of tumours was observed in the experimental groups of the animals as compared with control. Dibrospidium has been examined for the treatment of bone cancer. The oral route of administration is the most safe with respect to the oncogenic risk. It was noted that spirobromin exerted the most pronounced toxic action on erythrocytes. Dibrospidium is used for the treatment of acute leukemias (mainly in combinatio......

Gnidimacrin activated HIV-1 replication and killed persistently-infected cells at picomolar concentrations. In addition to its potential to purge HIV-1 from latently infected cells, gnidimacrin potently inhibited a panel of HIV-1 R5 virus infection of peripheral blood mononuclear cells (PBMCs) at an average concentration lower than 10 pM. These results suggest that gnidimacrin could activate latent HIV-1, specifically kill HIV-1 persistently infected cells, and inhibit R5 viruses at picomolar concentrations

ONX-0914 (PR-957) TFA is a selective, noncompetitive, irreversible inhibitor of the chymotrypsin-like subunit (LMP7) of the immunoproteasome, effectively blocking cytokine production and mitigating experimental arthritis progression. With a K_i value of 5.2 μM against the mycobacterial proteasome, ONX-0914 TFA also reactivates latent HIV-1 by inducing p-TEFb activation through HSF-1 mediation [1] [2] [3].

Livmoniplimab (ABBV-151; ARGX-115) is a humanised monoclonal antibody targeting LRRC32 (GARP)/TGFβ1, which blocks TGFβ1 release mediated by LRRC32, for the treatment of locally advanced or metastatic solid tumours.

Linavonkibart (SRK181) is a humanized antibody targeting TGFβ1 that blocks the release of TGF-β1 protein by specifically binding latent TGF-β1.

Leucomalachite Green-d6 is a deuterated compound of Leucomalachite Green. Leucomalachite Green has a CAS number of 129-73-7. Leucomalachite green is used in detecting latent bloodstains and in the forensic field because of convenience and cost/time-effectiveness.

Leuco Malachite Green-d5 is a deuterated compound of Leuco Malachite Green. Leuco Malachite Green has a CAS number of 129-73-7. Leucomalachite green is used in detecting latent bloodstains and in the forensic field because of convenience and cost time-effectiveness.

Leucomalachite Green-d6 (Standard) is the standard substance of Leucomalachite Green-d6, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Leucomalachite Green-d6 is a deuterated compound of Leucomalachite Green. Leucomalachite Green has a CAS number of 129-73-7. Leucomalachite green is used in detecting latent bloodstains and in the forensic field because of convenience and cost/time-effectiveness.

Echinatin exerts a protective effect against ischemia reperfusion (I R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil

IALYLQQNW is a specific nonapeptide sequence derived from the Epstein-Barr virus (EBV) encoded tumor-associated latent membrane protein 1 (LMP1). As a potential T-cell epitope, IALYLQQNW has the ability to activate EBV-specific cytotoxic T lymphocytes (CTLs), which can recognize and eliminate EBV-infected cells expressing LMP1. This peptide plays a vital role in the immune response against EBV-associated tumors and is utilized in research on Hodgkins disease and nasopharyngeal carcinoma.

Leucoberbelin blue I (LBB) is a latent color base that forms a colored complex when it undergoes oxidation by manganese through a hydrogen atom transfer reaction. LBB is applicable in the quantification or confirmation of Mn (II) oxide formation.