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Results for "

inflammation disease

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    85
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
SEW​2871
SEW2871
T2171256414-75-2
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.
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Cot inhibitor-1
T10865915365-57-0In house
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.
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6-8weeks
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Elubrixin
SB-656933
T11179688763-64-6In house
Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammation. Elubrixin is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist.
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6-8 weeks
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MEG hemisulfate
Mercaptoethylguanidine hemisulfate
T219673979-00-8In house
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS in tissue homogenates. It is notably effective as a peroxynitrite scavenger and blocks peroxynitrite-triggered oxidative mechanisms. Furthermore, this compound offers protective benefits across various experimental inflammation prototypes, such as ischemia reperfusion injury, hemorrhagic shock, periodontitis, inflammatory bowel disease, and both endotoxic and septic shock.
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MSDC-0602K
MSDC-0602K, Azemiglitazone potassium
T387151314533-27-1In house
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both individually and in combination with Liraglutide.
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Larsucosterol Ammonium salt
DUR-928 Ammonium salt, DUR928 Ammonium salt
T41015L2655654-16-1
Larsucosterol ammonium salt is the salt form of Larsucosterol (DUR-928) and a derivative of 25HC3S.Larsucosterol is a DNA methyltransferase inhibitor (DNMT), a potent hepatic X-receptor (LXR) antagonist, an endogenous oxysterol sulfate, and an epigenetic modulator, regulate lipid metabolism, reduce inflammation and treat liver disease.
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Metoprolol tartrate
CGP 2175E
T048756392-17-7
Metoprolol Tartrate is a blocker of the cardioselective β-adrenergic receptor.
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Perphenazine
Trilafon, Perphenazin, Etaperazine
T109058-39-9
Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
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kuwanon G
Moracenin B, Kuwanone G
T3S161275629-19-5
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has anti-inflammatory activity, it can attenuate atherosclerosis through inhibiting foam cell formation and inflammatory response. 3. Kuwanon G is a potent inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B. 4. Kuwanon G shows acetylcholinesterase (AChE) and butyrylcholinesterase(BChE) inhibitory activities, it may be a promising candidate for preventive and therapeutic agents for Alzheimer's disease. 5. Kuwanon G prevents the pathological progression of allergic asthma through the inhibition of lung destruction by inflammation and immune stimulation. 6. Kuwanon G has antibacterial activity against oral pathogens. 7. Kuwanon G is a specific antagonist for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.
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DPN
Diarylpropionitrile
T76441428-67-7
DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
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Letosteine
Viscotiol
T6052253943-88-7
Letosteine (Viscotiol) is an orally active, effective, and safe expectorant that can be used in the study of acute or chronic respiratory diseases, for example, bronchopulmonary disease. Letosteine dissolves bronchial mucus and reduces symptoms of respiratory inflammation and restores gas exchanges and natural defense mechanisms in the lung[1] [2] [3].
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6-8 weeks
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Sirtuin modulator 2
N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide
T9999667910-69-2
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.
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Neurotensin TFA
NEUROTENSIN TFA, Neurotensin TFA (39379-15-2 free base)
TP2309
Neurotensin TFA (39379-15-2 free base) is an endogenous 13 amino acid neuropeptide with profound opioid-independent analgesic effects. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders, and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems. It has a role as a human metabolite, a mitogen, a neurotransmitter and a vulnerary.
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IFB-088 acetate
T111959469866-31-7
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein disease, polyglutamine and polyalanine diseases, leukodystrophy, cystic fibrosis, multiple sclerosis, lysosome storage disorders, amyloidosis diseases, inflammation, metabolic disorders, cardiovascular diseases, osteoporosis, neurological trauma, and more.
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Gamma-glutamylcysteine TFA
γ-glutamylcysteine TFA
T11357283159-88-6
Gamma-glutamylcysteine TFA (γ-glutamylcysteine TFA) is a precursor of glutathione (GSH) with antioxidant and anti-inflammatory properties. It alleviates oxidative stress and mitochondrial damage induced by ethanol in hepatocytes by increasing cellular GSH, SOD activity, and mitochondrial membrane potential, protecting cells from alcohol-induced liver disease (ALD) by inhibiting oxidative stress, reducing inflammation, and preventing cell apoptosis.
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7-10 days
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Dilmapimod
SB-681323, GW 681323
T12850444606-18-2
Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK, potentially suppressing inflammation in chronic obstructive pulmonary disease.
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CDDO-dhTFEA
T136041191265-33-4
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).
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SCH 563705
T16864473728-58-4
SCH 563705 is an orally available and highly potent CXCR2 and CXCR1 antagonist for the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.
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10-14 weeks
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ZED-1227
ZED-101, TAK-227
T172891542132-88-6
ZED-1227 (TAK-227) is an orally active, selective and potent transglutaminase 2 (TG2) inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Disease.
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8-10 weeks
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PFI-2
PFI2, PFI 2, (R)-PFI-2
T19871627676-59-8
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki IC50: 0.33 2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
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1-2 weeks
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D228
D 228
T2005512676188-98-8
D228, a natural product from Chimonanthus salicifolius, is an orally available anti-inflammatory agent with favorable inhibitory activity on B and T lymphocytes, down-regulation of MyD88 TRAF6 p38 and up-regulation of IL-10 to reduce inflammation, and can be used for the treatment of inflammatory bowel disease (IBD).
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4-6 weeks
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ASP-8731
T2016872488255-42-9
ASP8731 is a selective inhibitor of BACH1 that prevents inflammation and vascular occlusion, and induces fetal hemoglobin in sickle cell disease.
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10-14 weeks
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AChE-IN-80
T204840
AChE-IN-80 (Compound 1) is an inhibitor of acetylcholinesterase (AChE). It suppresses inflammation and reactive oxygen species (ROS) production in cultured neurons and microglia, induces autophagy, and prevents the spread of beta-amyloid (Aβ) fibrils. AChE-IN-80 exhibits antioxidant activity and neuroprotective effects, making it valuable for Alzheimer's disease research.
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PDE4-IN-26
T205303
PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.
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