il11

Expression system: E. coli
Length: 22-199, Full Length of Mature Protein
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 22-199, Full Length of Mature Protein
Activity: Not Tested

IL-11 Protein, Rat, Recombinant (hFc) is expressed in Mammalian cell. The accession number is Q99MF5.

Expression system: HEK293 Cells
Length: 22-199, Full Length of Mature Protein
Activity: Not Tested

Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. It also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2, It activates a signaling cascade that promotes cell proliferation. The signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.

Expression system: HEK293 Cells
Length: 22-199, Full Length of Mature Protein
Activity: ELISA、SPR

Expression system: HEK293 Cells
Length: 22-199, Full Length of Mature Protein
Activity: SPR

IL-11 Protein, Human, Recombinant (hFc) is expressed in CHO Cells. The accession number is P20809-1.

IL-11 Protein, Human, Recombinant (CHO) is expressed in CHO Cells. The accession number is P20809-1.

IL-11 Protein, Mouse, Recombinant (HEK293) is expressed in HEK293 Cells. The accession number is P47873.

IL-11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.1 kDa and the accession number is AAH12506.1.

IL-11 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.2 kDa and the accession number is A3KPB8.

Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.