hemoglobin

Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.

RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).

FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.

Efaproxiral Sodium (RSR13 sodium), a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.

Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, capable of transporting oxygen from the lungs to tissues. Haemoglobin is a multifunctional molecule involved in numerous enzymatic catalysis, nitric oxide metabolism, pH regulation, and maintaining redox balance, amongst other functions.

Hemoglobin, which is the primary cause of sickle cell disease (SCD) abnormalities, can be utilized to determine fetal hemoglobin through time-resolved immunofluorescence assay [1].

Hemoglobin (64-76) is a polypeptide molecule with the sequence GKKVITAFNEGLK.

MouseHemoglobin is a hemoglobin derived from mice. Hemoglobin is an iron-containing protein in red blood cells with oxygen-binding properties. It acts as an HO-1 inducer and consists of heme, enabling oxygen binding. Hemoglobin also transports gases such as carbon dioxide, nitric oxide, hydrogen sulfide, and other sulfides. Additionally, it absorbs excess oxygen in tissues, functioning as an antioxidant.

Guinea Pig Hemoglobin is a hemoglobin derived from guinea pigs. Hemoglobin is an iron-containing protein in red blood cells with oxygen-binding capabilities. It acts as an HO-1 inducer and is composed of heme, which can bind to oxygen. Furthermore, hemoglobin transports other gases such as carbon dioxide, nitric oxide, hydrogen sulfide, and sulfides. It also absorbs excess oxygen in tissues, functioning as an antioxidant.

Hemoglobin is an iron-containing protein found in red blood cells, noted for its ability to bind oxygen. As an HO-1 inducer, hemoglobin consists of heme groups capable of binding oxygen. Additionally, hemoglobin transports other gases such as carbon dioxide, nitric oxide, hydrogen sulfide, and sulfides. It also functions as an antioxidant by absorbing unwanted oxygen from tissues.

RabbitHemoglobin is a hemoglobin derived from rabbits. Hemoglobin is an iron-containing protein in red blood cells with oxygen-binding properties. It acts as an HO-1 inducer and consists of heme, which can bind with oxygen. Hemoglobin also transports gases such as carbon dioxide, nitric oxide, hydrogen sulfide, and sulfides. Additionally, it absorbs excess oxygen in tissues and serves as an antioxidant.

Hemoglobin-CoA (Hemoglobin-coenzyme A) is a derivative of coenzyme A.

Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).

TN1 is a potent inducer of fetal hemoglobin (HbF).

Vasicinol (6-Hydroxypeganine), a pyrroloquinazoline alkaloid isolated from Adhatoda vasica (L.), Nees, is a sucrase inhibitor that inhibits the sucrose hydrolyzing activity of rat intestinal α-glucosidase, with a Ki value of 183 μM.Vasicinol is a HbF inducer. Vasicinol is an HbF inducer and can be used to study metabolic disorders and diabetes.

Iptacopan hydrochloride (LNP023 hydrochloride) is a small-molecule inhibitor and a complement factor B inhibitor (IC50 = 10 nM, KD = 7.9 nM) with high selectivity, oral activity, and cell permeability, used for the treatment of complement-mediated diseases including paroxysmal nocturnal hemoglobinuria, IgA nephropathy, and C3 glomerulopathy.

3-(3,4-Dimethoxyphenyl)propanoic acid (3,4-Dimethoxyhydrocinnamic acid) is an orally active short-chain fatty acid (SCFAs) that promotes γ-globin gene expression and erythropoiesis in vivo, making it useful in treating beta hemoglobinopathies and other anemias.

Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM

Pepstatin (Pepsin Inhibitor S 735A) is an aspartate protease inhibitor that also inhibits HIV protease activity with specific and oral activity. Pepstatin inhibits autophagy.

L-Isoleucine (Ile) is an essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.

D-Cysteine, the D-isomer of cysteine, is a powerful inhibitor of E. coli growth and is mediated by D-amino acid oxidase to produce H2S, serving as a neuroprotective agent against cerebellar ataxia. Additionally, D-cysteine can inhibit the growth and cariogenicity of a two-species biofilm formed by Streptococcus mutans and Streptococcus hemoglobin.

D-Pantothenic acid (vitamin B5) is an essential micronutrient and a precursor to coenzyme A. D-Pantothenic acid participates in the metabolism of the three major nutrients—fat, carbohydrates, and protein—within the body. D-Pantothenic acid also plays a crucial role in skin barrier repair, maintaining hematopoietic function, and synthesizing adrenal hormones.

Ferroheme (protoheme) is the color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins. A Ferroheme or haem is a prosthetic group that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin.

BMS-986470 is a CRBN E3 ubiquitin ligase modulator (CELMoD) that activates fetal hemoglobin (HbF). It is an orally available molecular glue degradator targeting ZBTB7A and WIZ protein degradation, thereby inducing gamma globin synthesis and activating HbF. It is applicable for studying sickle cell disease (SCD).