glur5

UBP310 (UBP 310) is a GLUK5 kainate receptor antagonist

mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor with an IC50 of 11.5 nM, demonstrating antidepressant effects [1].

mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment research.

LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.

LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA) receptors.

Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures. Topiramate has been rarely associated with hepatic injury and largely when used in combination with other anticonvulsant medications.

GluR5-subunit containing kainate receptor antagonist

Topiramate lithium (McN 4853) is a broad-spectrum antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action includes enhancing GABAergic activity, inhibiting kainate AMPA receptors, voltage-sensitive sodium and calcium channels, and increasing potassium conductance. Additionally, this compound inhibits carbonic anhydrase. [1][2][3]

Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor.

LY339434 is a potent and selective agonist of the kainate receptor, specifically targeting GluK1 and GluR5.

GluR5-containing kainate receptor antagonist

ATPA is a selective glutamate receptor GluR5 activator (EC50s: 0.66, 1.4, 9.5, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S721T), GluR5(S741M), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V)).

Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.