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  • DUB
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Results for "

dubs

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    42
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    1
    TargetMol | Compound_Libraries
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
BAY 11-7082
BAY 11-7821
T190219542-67-7
BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that suppresses TNFα-induced IκBα phosphorylation (IC50=10 μM) and also inhibits the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19 0.96 μM).
  • $43
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TargetMol | Inhibitor Hot
n-ethylmaleimide
NEM, Ethylmaleimide, 1-Ethyl-1H-pyrrole-2,5-dione
T3088128-53-0
N-Ethylmaleimide (NEM) is a reagent for alkylation of free sulfhydryl groups, a cysteine protease inhibitor used in experimental biochemistry. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor that specifically inhibits phosphate transport in mitochondria.
  • $39
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ML-323
ML323
T17571572414-83-5
ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (IC50: 820 nM) as substrates, respectively.
  • $60
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PR-619
PR 619, 2,6-Diamino-3,5-dithiocyanopyridine
T18622645-32-1
PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor that inhibits USP2 4 5 7 8 (EC50=7.2 3.93 8.61 6.86 4.9 μM). PR-619 induces endoplasmic reticulum stress and activates autophagy.
  • $45
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TargetMol | Inhibitor Sale
DUB-IN-2
T11111924296-19-5
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
  • $72
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DUB-IN-3
T11112924296-17-3
DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor with an IC50 of 0.56 μM for USP8.
  • $139
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EOAI3402143
T112091699750-95-2
EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.
  • $61
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GNE-6776
GEN6776
T46342009273-71-4
GNE-6776 is a selective USP7 inhibitor.
  • $74
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USP30 inhibitor 18
T366822242582-40-5In house
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.
  • $147
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6-Thioguanine
6-TG, 2-Amino-6-purinethiol, 2-Amino-6-mercaptopurine, Thioguanine
T3089154-42-7
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
  • $40
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GRL0617
T114641093070-16-6
GRL0617 is a selective and competitive noncovalent inhibitor of SARS-CoVPLpro and deubiquitinase (IC50: 0.6 μM, Ki: 0.49 μM).
  • $31
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LDN-57444
LDN57444
T1924668467-91-2
LDN-57444 is a reversible, competitive inhibitor of the proteasome Uch-L1 with an IC50 of 0.88 μM.
  • $34
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TargetMol | Inhibitor Sale
B-AP15
NSC 687852
T19321009817-63-3
B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome.
  • $32
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P 22077
P22077
T24241247819-59-5
P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
  • $32
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ML364
T35551991986-30-1
ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.
  • $66
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IU1
T6107314245-33-5
IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
  • $54
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Degrasyn
WP1130
T6300856243-80-6
Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT).
  • $35
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P005091
P5091
T6925882257-11-6
P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
  • $39
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RA-9
T8464919091-63-7
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs) with a favorable toxicity profile and anticancer activity, particularly effective in inducing apoptosis in ovarian cancer cell lines.
  • $37
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DUB-IN-1
T11110924296-18-4
DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
  • $59
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TargetMol | Inhibitor Sale
MF-094
T120242241025-68-1
MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.
  • $36
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TargetMol | Inhibitor Hot
USP7-IN-1
T132681381291-36-6
USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 77 μM.
  • $98
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C527
T14852192718-06-2
C527 is a potent pan DUB enzyme inhibitor with a high affinity for the USP1 UAF1 complex (IC50=0.88 μM).
  • $29
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HBX 19818
T154641426944-49-1
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
  • $32
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