change — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11399	Giredestrant	GDC-9545	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Giredestrant (GDC-9545) potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand,...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T125179	Archangelicin
	Archangelicin is a useful organic compound for research related to life sciences. The catalog number is T125179 and the CAS number is 2607-56-9.
T25373	EMD57439	EMD-57439,EMD 57439	PDE
	EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).		PDE
T5S1261	Methylophiopogonanone B		Ras
	1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.		Ras
T16859	SBI-425		Others
	SBI-425 is an effective and orally bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP). SBI-425 effectively inhibits TNAP in the vasculature and improves cardiovascular parameters and survival withou...		Others
T3237	Lecithin	Phospholutein,L-α-Phosphatidylcholine,Phosphatidylcholines	Others , Endogenous Metabolite
	Lecithin (L-alpha-phosphatidylcholine) is considered a safe source of conventional phospholipids. Phospholipids can change the fatty acid composition and microstructure of animal cell membrane.		Others , Endogenous Metabolite
T11179	Elubrixin	SB-656933	IL Receptor , CXCR
	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat...		IL Receptor , CXCR
T8799	(E/Z)-IT-603	IT603	Others , NF-κB
	(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor (IC50: 3μM). IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity.		Others , NF-κB
T35353	Elubiol	dichlorophenyl imidazoldioxolan	Antibacterial
	Elubiol (dichlorophenyl imidazoldioxolan) is a new broad-spectrum antifungal product of imidazole, which can inhibit the biosynthesis of fungal ergosterol and change the composition of other lipid compounds in the cell m...		Antibacterial
T6778	BDA-366		BCL
	BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-ap...		BCL
T4713	Phosphorylcholine chloride calcium salt tetrahydrate	Phosphocholine chloride calcium salt tet,CalciuM Phosphorylcholine Tetrahydrate	Others , Endogenous Metabolite
	Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) is a small haptenic molecule, is found in a wide variety of organisms. Human hepatic tumors undergo an elevation in the conc...		Others , Endogenous Metabolite
T19658	Enflurane	NSC115944,Ethrane,NSC-115944,Efrane,NSC 115944	Others
	Enflurane (Efrane), a volatile anaesthetic, is a potent inhibitor of high conductance Ca2+-activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by he...		Others
T5S0527	Rhodojaponin III		Others
	1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodoja...		Others
T31495	Dimethylmyleran
	Dimethylmyleran can promote Haematological change and affect spermatogenesis.
T69252	CPD26
	CPD26 is a novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein.
T24740	RS-104966
	RS-104966 is an inhibitor of collagenase that acts by inducing the conformational change in the side-chains of the S1 pocket of MMP-1.
T68310	CPD7
	CPD7 is a novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein.
T15565	Imetit dihydrobromide	VUF 8325 dihydrobromide,SKF 91105 dihydrobromide	Histamine Receptor
	Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).		Histamine Receptor
T71989	CPD7 HCl
	CPD7 HCl is a novel non-RBD binding modulator to inhibit SARS-CoV-2 by prohibiting the conformational change of the spike (S) protein.
T28099	MRS2179	MRS 2179,MRS-2179
	MRS2179 is a competitive P2Y1 receptor antagonist (Kb = 100 nM) with no appreciable activity at P2Y2, P2Y4, or P2Y6 at concentrations up to 30 µM, or at P2Y12 and P2Y13. It inhibits ADP-induced platelet shape change and ...