camptothecin

Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.

Sodium Camptothecin is a plant alkaloid with antitumor activity. Sodium Camptothecin is a reversible RNA synthesis inhibitor. Sodium Camptothecin is an effective adenovirus replication inhibitor. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA.

10-Nitro-camptothecin is a natural product

(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma.

9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.

(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

10-Methoxycamptothecin, a natural bioactive derivative of camptothecin (CPT) isolated from *Camptotheca acuminata*, exhibits potent anti-cancer properties.

12-Ethyl-9-hydroxycamptothecin (SN38) is the active metabolite of irinotecan, a topoisomerase I inhibitor, with potential anticancer activity for use in the study of colon and rectal cancer.

1. 7-Ethylcamptothecin has the superior antitumor activity than CPT. (a). 7-Ethylcamptothecin has a stronger growth-inhibiting activity against tumor cells. (b). 7-Ethylcamptothecin remains in the intestinal tract for a longer time and in higher amounts when administered in vivo.

9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.

(20S)-18,19-Dehydrocamptothecin, a natural product, can be isolated from Nothapodytes foetida [1].

9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.