ar a 2

AR-A 2 is a selective 5-HT1B receptor antagonist with high affinity to guinea pig cortex 5-HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM), exhibiting a 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).

A2AR/A2BR antagonist 1 (compound 7ai) acts as a dual antagonist to A2AR and A2BR with IC50 values of 11.2 nM and 6.4 nM, respectively. Additionally, A2AR/A2BR antagonist 1 enhances T cell-mediated cancer cell death.

A2AR-agonist-1 (N-(2-(1H-Indol-3-yl)ethyl)adenosine) is a potent A2AR and ENT1 agonist (Ki: 4.39 and 3.47 for A2AR and ENT1. It targets the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection.

1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986. S 18986 is a AMPA receptor positive modulator with EC2 (Concentration that doubles the intensity of the AMPA-induced current) of 35 μM.

β2AR/M-receptor agonist-2 is a dual-function compound acting as a muscarinic antagonist and β2 adrenoceptor agonist (MABA). It demonstrates significant activity towards the β2 adrenoceptor with an EC50 of 3.7 nM and exhibits affinity for the human cloned M3 receptor with a Ki of 0.73 nM. This potent bronchodilator holds potential for research in chronic obstructive pulmonary disease (COPD) treatment.

Cyclopenta[c][1]benzopyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aR,4S,9bS)-rel- is an estrogen receptor beta (ERβ) agonist.

β3-AR agonist 2 is a potent and selective agonist of β3-adrenergic receptor (β3-AR with an EC50 of 8 nM).

A1AR antagonist 2 (compound 18h) is a potent antagonist of the A1 adenosine receptor (AR) with Ki values of 1.49, 10.2, and 50.1 nM for hA1, hA2A, and hA2B, respectively [1].

AR antagonist 2 (compound 58) is a potent inhibitor of the androgen receptor (AR) with an IC50 of 0.95 μM.

AR Degrader-2 (Compound 2) is a degrader of the androgen receptor (AR), exhibiting a DC50 range of 0.3-0.5 μM in VCaP cells.

methyl 2-[(1S,2S,4aR,8R)-1,8-dihydroxy-4a,8-dimethyl-decahydronaphthalen-2-yl]prop-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(2R,3S,4aR,5S,7R)-4a,5-dimethyl-3-(prop-1-en-2-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalene-2,7-diol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1R,2R,8aR)-2-hydroxy-2,5,5,8a-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(3aR,4aR,8aR,9aR)-4a-hydroxy-8a-methyl-3,5-dimethylidene-dodecahydronaphtho[2,3-b]furan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[(1S,2R,4aR)-1,2,4a,5-tetramethyl-7-oxo-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]-3-methylpentanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4aR,5S)-9-hydroxy-3,4a,5-trimethyl-2H,4H,4aH,5H,6H,7H,8H,8aH,9H,9aH-naphtho[2,3-b]furan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(4aR,5S)-9,9a-dihydroxy-3,4a,5-trimethyl-2H,4H,4aH,5H,6H,7H,8H,8aH,9H,9aH-naphtho[2,3-b]furan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1S,2S,8aR)-1-[(3Z)-5-hydroxy-3-methylpent-3-en-1-yl]-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice.

hA3AR agonist 2 is a potent activator of A3AR, with a Ki value of 3.5 nM.

β2AR agonist 2 (compound 8a) is an agonist of the β2-adrenergic receptor (β2AR). It is a saturated azacyclic compound featuring a 4- to 7-membered heterocycle. The compound has a chiral structure in the -R form by incorporating a carbon with a requisite hydroxyl group, which significantly stimulates glucose uptake in skeletal muscle cells, thereby enhancing cellular glucose uptake (GU). β2AR agonist 2 is applicable in the study of type 2 diabetes (T2D).

β2AR agonist 4 (compound A19) is an effective selective agonist for the β2-adrenoceptor (β2-Adrenoceptor), exhibiting an EC50 of 3.7 pM. In a rat model with COPD, β2AR agonist 4 reduces the elevation of inflammatory factors and leukocytes, thereby improving lung function.

Compound 4, known as β2AR ligand 1, serves as a bivalent ligand for the β2-adrenergic receptor (β2AR) at both the orthosteric binding site (OBS) and the metastable binding site (MBS).

α2AR agonist 1 (compound S6a) is a morpholinopyrimidinone that serves as an agonist for the α2-adrenergic receptor (α2AR). This compound elicits a concentration-dependent relaxation in precontracted aortic rings induced by phenylephrine (pEC50=6.81). Additionally, α2AR agonist 1 elevates levels of NOx and NO in HUVEC.