acetylcoa carboxylase

Moiramide B is a potent acetyl coenzyme A carboxylase (ACC) inhibitor (IC50:6 nM) with antimicrobial activity, strongly inhibiting Gram-positive bacteria but weakly inhibiting Gram-negative bacteria.

CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.

CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). It has been used in trials studying the treatment of Acne Vulgaris.

CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.

TOFA (MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).

(±)-Haloxyfop (Haloxyfop Acid) is a herbicide.

PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively

Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)

Quizalofop-P, a selective herbicide, is absorbed by weed stems and leaves before translocating both upward and downward within the plant, concentrating in apical and intercalary meristems. It inhibits fatty acid synthesis at the cellular level, leading to weed necrosis, and exhibits high selectivity between grass weeds and dicotyledonous crops [1].

PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.

ND-646 is an orally bioavailable and allosteric inhibitor of the ACC enzymes ACC1 and ACC2, with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.

Clodinafop-propargyl is a post-emergence herbicide belonging to the propionic acid arylphenoxy (AOPP) class, inhibiting acetyl-CoA carboxylase (ACCase), and is used for annual grass weeds.

Tralkoxydim (Tralkoxydime) is an alkyl ketone herbicide. Tralkoxydim works as an ACCase inhibitor.

MK-4074 is a liver-specific acetyl-CoA carboxylase (ACC1 and ACC2) inhibitor with an IC50 of 3 nM.

Quizalofop-p-ethyl ((R)-Quizalofop ethyl) is a selective post-emergent herbicide for use on annual and perennial weeds, acting as an acetyl-CoA carboxylase (ACCase) inhibitor leading to weed death.

Cyhalofop-butyl is an ACCase (acetyl-coenzyme A carboxylase) inhibitor and herbicide that suppresses plant lipid synthesis at the meristematic level.

Quizalofop-ethyl (NC 302) is a aryloxyphenoxypropionate herbicide used for post-emergence control of annual and perennial grass weeds within broadleaf crops such as soybeans, cotton, and peanuts, and its herbicidal activity is mediated through the potent inhibition of the acetyl-CoA carboxylase (ACCase) enzyme.

(Rac)-Spirotetramat-enol (Compound 8) serves as a ligand for target proteins, utilized in the synthesis of PROTAC ACC degrader.

AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).

Clethodim is a selective herbicide used to control annual and perennial grass species by inhibiting acetyl-CoA carboxylase activity. Clethodim is characterized by high water solubility, low volatility, and limited environmental persistence in soil and aquatic systems, with moderate toxicity to birds, fish, and pollinators such as honeybees, yet relatively low toxicity toward aquatic invertebrates and algae, thereby making it an effective yet environmentally manageable agrochemical.

THR-β agonist 9 is a potent and selective THR-β activator, which shows sensitivity to His435 mutations with an EC50 of 3.2 nM. It demonstrates moderate selectivity, approximately 10-fold, and effectively activates various His435 mutants (H435A, H435Y, and H435R), with EC50 values ranging from 134.2 nM to 515.5 nM. THR-β agonist 9 presents potential for research into conditions such as dyslipidemia, metabolic syndrome-associated steatohepatitis (MASH), and resistance to thyroid hormone (RTH).

ACC-IN-1 (Compound B1) is an allosteric inhibitor of acetyl-CoA carboxylase (ACC). It targets ACC to regulate lipid metabolism, potentially improving liver steatosis and inflammation associated with non-alcoholic steatohepatitis (NASH).

Insecticidal agent 26 (Compound A11) is a spirocyclic insecticide that serves as a dual inhibitor of acetyl-coenzyme A carboxylase (ACC) and pyruvate carboxylase (PC) in pests. It exhibits potent insecticidal activity against Sogatella furcifera with an LC50 of 11.0 μg/mL while maintaining good environmental safety for bees. Insecticidal agent 26 is effective for the control of white-backed planthoppers (WBPs).