a-neurokinin

Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .

Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, functions via the NK-2 receptor and acts as a key mediator in human airway and gastrointestinal tissues [1].

Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist [1].

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, is a selective and potent NK2 receptor (NK2R) agonist with prokinetic activity, making it valuable for researching smooth muscle contractions across various tissues through NK-2 receptor engagement [1][2][3].

(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective agonist for the NK-2 tachykinin receptor [1].

(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent neurokinin-3 (NK3) antagonist [1].

Tyr0-Neurokinin A, a member of the tachykinin peptide family, acts as an agonist for the Tacr2 receptor. It is utilized in research focused on insulin resistance, obesity, and diabetes [1] [2].

Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].

gamma-preprotachykinin amide (72-92) acetate is a 21 amino acid peptide belonging to the tachykinin (TK) family and including neurokinin A (NKA) in its C-terminal sequence. gamma-preprotachykinin amide (72-92) acetate possesses higher affinity than NKA for central NK-2 receptors; it shows lower affinity for NK-1 receptors, however, it potently stimulates salivary secretion, which is mediated by NK-1 receptor activation.

Scyliorhinin II acetate is a selective agonist of the neurokinin-3 (NK3) receptor (Ki = 2.5 nM) in rat cerebral cortex.

Physalaemin acetate is a non-mammalian tachykinin with high affinity when binding selectively to neurokinin-1 (NK1) receptor.

GR 94800 acetate is a potent and selective neurokinin 2(NK-2) antagonist.

Biotin-Substance P acts as a neurotransmitter and neuromodulator in the central nervous system. Neurokinin 1 receptor (NK1R) is the endogenous receptor of Biotin-Substance P.

Hemokinin 1, human TFA acts as a selective full agonist at the tachykinin neurokinin 1 (NK1) receptor, while also being a full agonist at NK2 and NK3 receptors. It is capable of inducing opioid-independent analgesia [1] [2].

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is an analogue of Substance P that acts on the neurokinin 1 receptor (NK1R) in rat brain, similarly to Substance P but with a significantly extended duration of action. This compound selectively enhances dopamine metabolism within the mesencephalon and midbrain cortex, increases motor activity, and facilitates the resumption of addictive agent-seeking behavior in rats [1] [2] [3].

[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with inhibitory affinities (K_i values) of 1 μM for NK-1, 1.3 μM for NK-2, and approximately 9 μM for NK-3 receptors [1].

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist that effectively inhibits the actions of gold-protein-substance P (GPSP) and substance P (SP), demonstrating its efficacy in neutralizing their effects [1].

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B functions as a competitive antagonist to the Neurokinin B receptor with a pA2 value of 5.5, and does not affect Substance P or Neurokinin A [1].

Neurokinin Receptor (393-407), rat (SPR393–407), a fragment of the rat neurokinin 1 receptor (NK1R), undergoes rapid endocytosis and recycling to the plasma membrane upon substance P (SP) binding and is instrumental in researching neurogenic inflammation [1] [2].

GR 83074 is a potent and selective antagonist of the NK-2 (Neurokinin Receptor) with a 340-fold selectivity over NK-1 and a pK_B value of 8.23. It does not act as an antagonist for NK-3, affirming its specificity [1].

Biotin-Neurokinin A, a biotinylated form of Neurokinin A (Substance K), functions as a peptide neurotransmitter within the tachykinin family, primarily engaging the NK-2 receptor. It serves as a significant mediator in the physiological processes of human airway and gastrointestinal tissues [1].

[MePhe7]-Neurokinin B is a neurokinin NK-3 receptor (NK3R) agonist, exhibiting a potent agonistic activity with an IC50 value of 3 nM. It acts as a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion through the activation of NK3R [1].