H1N1

CBS1117 is a virus entry inhibitor with an IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1). It interferes with the hemagglutinin (HA)-mediated fusion process.

Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidases (NAs), particularly H1N1 and H5N1 neuraminidases, with IC50 values of 4.6 and 10.9 μM, respectively.

ML303 is an antagonist of pyrazolopyridine influenza virus nonstructural protein 1 (NS1) (IC90 : 155 nM).

Neuraminidase-IN-1 (Compound Y-1) is a novel neuraminidase inhibitor.

Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs.

Eckol inhibits ultraviolet B-induced cell damage by a decrease in oxidative stress in human keratinocytes.This compound is unstable in powder form and other related salt forms are recommended.

Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.

PP7 is a potent inhibitor of PB1-PB2 interaction(IC50 of 8.6 μM).

VNT-101 is an orally active influenza A virus (IAV) inhibitor with potent antiviral activity against multiple influenza A virus subtypes.

Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.

1. Dendrobine has a slight but demonstrable analgesic and antipyretic action. 2. Dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers the blood pressure. 3. Dendrobine on the electrical activity and on amino acid-induced depolarizations of primary afferent terminals were tested on the frog isolated spinal cord.

U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity. U0126-EtOH inhibited autophagy and mitophagy.

β-Cyclodextrin (NSC 269471) is a member of the class of compounds known as oligosaccharides.

MBX2329 is a specific inhibitor of HA-mediated viral entry that inhibits H1N1 virus strain high pathogenic avian influenza H5N1 virus strain.

DPQ is an antiviral compound. DPQ has also been shown to bind to a widened RNA major groove at the internal loop. DPQ acts against the H1N1 and H3N2 strains of influenza A as well as influenza B.

Antiviralagent 65 (compound 9) is an antiviral agent targeting the H1N1 influenza virus, with an EC50 of 7 μg/mL.

Neuraminidase-IN-23 (33c) is a potent inhibitor of the neuraminidase enzyme (NA) targeted against influenza viruses. It exhibits inhibitory concentration (IC50) values of 0.049 μM for H1N1, 0.26 μM for H3N2, 0.17 μM for H5N1, 0.013 μM for H5N8, and 0.74 μM for H5N1-H274Y.

ATV2301 is an orally potent anti-influenza compound with an EC50 of 1.88 nM for H1N1 and 4.77 nM for H3N2. Its anti-influenza activity results from its impact on polymerase acidic protein (PA), nucleoprotein (NP), and RNA-dependent RNA polymerase (RdRp).

Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active cap-dependent endonuclease (CEN) inhibitor. It serves as an antiviral agent with activity against influenza B virus. Additionally, Cap-dependent endonuclease-IN-27 inhibits the polymerase of IFV A/WSN/33 (H1N1) with an EC50 of 12.26 nM.

Influenza A virus-IN-14 (Compound 37) is an inhibitor of the influenza A virus (IAV), effectively suppressing H1N1 with an EC50 of 23 nM. It demonstrates low cytotoxicity, with a CC50 exceeding 100 μM, and reduces cytopathic effects while enhancing the survival rate of Calu3 cells. The compound exhibits synergistic effects with the neuraminidase inhibitor Oseltamivir. However, it shows poor pharmacokinetic properties in CD-1 mice.

Antiviralagent 70 (Compound 12b) is an antiviral agent with exceptional binding affinity for neuraminidase (Neuraminidase). It exhibits potent antiviral activity against the H1N1 influenza virus, with an IC50 of 2.9 μM. This compound is applicable for research on influenza virus infections.

VF-57a (Compound 23) is an inhibitor of Influenza A virus (IAV) fusion. It exhibits potent antiviral activity against the real A/H1N1 virus, with EC50 values of 0.92 μM for the A/H1N1 PR8 strain and 0.31 μM for the A/H1N1 Virg09 strain. VF-57 significantly inhibits cell entry of HA-mediated A/H1N1 and A/H5N1 pseudoviruses and prevents HA refolding at pH 5.2. VF-57a is utilized in IAV infection research.

PAC/NP-IN-1 (Compound 30) is a dual-target influenza inhibitor that specifically binds to nucleoprotein (NP) and the C-terminal domain of the PA protein (PAc). It inhibits the influenza A virus A/WSN/33 (H1N1) with an EC50 of 3.63 μM and an IC50 of 3.08 μM. PAC/NP-IN-1 is utilized in influenza infection research.

Influenza virus-IN-10 is a dual-target anti-influenza compound that simultaneously targets PAC (KD = 8.9 μM) and NP (KD = 52.5 μM). Its EC50 value against the influenza A virus (H1N1, A/WSN/33) is 1.64 μM, and it exhibits broad-spectrum activity against other influenza strains, including influenza B virus and various influenza A subtypes.