clk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23897	CLK1/2-IN-3	CLK1/2 inhibitor 3,CLK1/2-inhibitor-3,CLK1/2 IN 3,CLK1/2IN3	CDK
	CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK1/2-IN-3 induces nuclear speckle enlargement, wh...		CDK
T72039	CLK1-IN-3		DYRK , CDK , Autophagy
	Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly effective inhibition of Clk2 and Clk4, with IC50 values of 4...		DYRK , CDK , Autophagy
T23896	CLK1/2-IN-1	CLK1/2 inhibitor 1,CLK1/2IN1,CLK1/2-inhibitor-1
	CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.
T10836	CLK1-IN-1		CDK
	CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).		CDK
T24439	MDK6204	CLK1/2 IN 2,CLK1/2IN2,CLK1/2-inhibitor-2,CLK1/2-IN-2,CLK1/2 inhibitor 2
	MDK6204 is a selective inhibitor of CLK1 and CLK2.
T73321	CLK1-IN-2
	CLK1-IN-2, a metabolically stable Clk1 inhibitor, exhibits selective activity for Clk1 with an IC50 value of 1.7 nM. It is applicable in researching tumor, Duchenne's muscular dystrophy, and viral infections including HI...
T61543	CLK1/4-IN-1
	CLK1/4-IN-1 (compound 31) is a highly potent and selective inhibitor of Clk1 and Clk4, with IC50 values of 9.7 nM and 6.6 nM, respectively. It effectively inhibits the growth of T24 cancer cells, with a GI50 value of 1.1...
T74805	T74805
	CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC 50 of 5 nM and over 300-fold selectivity for Dyrk1A . CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4 , with IC 50 ...
T8418	DCLK1-IN-1		Others
	DCLK1-IN-1 is a selective and in vivo-compatible chemical probe of the DCLK1 kinase domain .		Others
T79421	DCLK1-IN-2
	DCLK1-IN-2 (Compound I-5) is a potent inhibitor of DCLK1, exhibiting an IC50 of 171.3 nM, and demonstrates significant antiproliferative effects on SW1990 cell lines with an IC50 of 0.6 μM, as well as in vivo antitumor p...
T14980	CLK-IN-T3		DYRK , CDK
	CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.		DYRK , CDK
T8801	SRI-29329		CDK
	SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).		CDK
T13058	T025		CDK
	T025 is a pan CLK inhibitor with Kds of 4.8, 0.096, 6.5, 0.61, and 0.074 nM for CLK1-4, respectively. T025 displays anti-proliferative activities with IC50s of 30-300 nM in hematological and solid cancer cell lines. T025...		CDK
T1901	(E/Z)-TG003	TG003	BCL , CDK
	(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.		BCL , CDK
T15657	KH-CB19		Others
	KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).		Others
T60367	TG003
	TG003, a potent inhibitor of Clk1/Sty, exhibits inhibitory activity against Clk1 and Clk4 with IC50 values of 20 nM and 15 nM, respectively [1].
T38757	KH-CB20	KH-CB20
	KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and CLK4 , with an IC 50 of 16.5 nM for CLK1 . KH-CB20 also can inhibits DYRK1A ( IC 50 =57.8 nM) and CLK3 ( IC 50 =488 nM).
T60394	Haspin-IN-2
	Haspin-IN-2 (compound 4) is a potent, selective inhibitor of haspin, exhibiting an IC50 of 50 nM. Additionally, it inhibits CLK1 and DYRK1A, with IC50 values of 445 nM and 917 nM, respectively [1].
T61985	EHT 5372
	EHT 5372 is a potent and selective inhibitor of DYRK’s family kinases. EHT 5372 shows IC 50 s of 0.22, 0.28, 10.8, 93.2, 22.8, 88.8, 59.0, 7.44, 221 nM for DYRK1A, DYRK1B, DYRK2， DYRK3， CLK1, CLK2, CLK4, GSK-3α, GSK-3β.
T79562	Leucettinib-92		CDK
	Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), ...		CDK
T21950	K 00546
	K00546, a potent inhibitor of both cyclin-dependent kinase (CDK1 and CDK2) and CDC2-like kinase (CLK1 and CLK3), demonstrates high specificity with IC50s of 0.6 nM and 0.5 nM for CDK1/cyclin B and CDK2/cyclin A, respecti...
T2670	ML167	NCGC00188654,CID44968231	DYRK , CDK
	ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.		DYRK , CDK
T66481	TG-693
	TG693, an orally available inhibitor of CLK1, promotes the skipping of the endogenous mutated exon 31 in Duchenne muscular dystrophy (DMD) patient-derived cells and increased the production of the functional exon 31-skip...
T60477	Haspin-IN-1
	Haspin-IN-1 (compound 2a) is an inhibitor of haspin (haploid germ cell-specific nuclear protein kinase) with an IC50 of 119 nM. Haspin-IN-1 also inhibits CLK1, DYRK1A, and CDK9 with IC50 of 221 nM, 916.3 nM, and 406.8 nM...
T63101	CJ-2360
	CJ-2360 is a potent, orally active ALK inhibitor, capable of acting on wild-type ALK (IC50: 2.2 nM) and F1197M (IC50: 4.0 nM), G1269A (IC50: 8.8 nM), L1196M (IC50: 6.3 nM) and S1206Y ALK mutant (IC50: 8.9 nM). CJ-2360 st...
T36684	Ipivivint
	Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 μM), CLK2 (IC50=0.002 μM) and CLK3 (IC50=0.022 μM). Ipivivint reduces Wnt pathway signaling gene expression t...
T38562	AKN-028		FLT
	AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.		FLT
T14367	AZ1495		IRAK , CDK , Haspin Kinase
	AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu...		IRAK , CDK , Haspin Kinase
T15204	EHT 1610	EHT 5372	GSK-3 , NF-κB , Tyrosinase , DYRK , CDK
	EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, regulating cell cycle and inducing cell apoptosis...		GSK-3 , NF-κB , Tyrosinase , DYRK , CDK
T12102	Mps1-IN-1		Others
	Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )		Others

Compounds

CLK1/2-IN-3

T23897

Synonym: CLK1/2 inhibitor 3,CLK1/2-inhibitor-3,CLK1/2 IN 3,CLK1/2IN3

Target: DYRK, CDK, Autophagy

CLK1/2-IN-1

T23896

Synonym: CLK1/2 inhibitor 1,CLK1/2IN1,CLK1/2-inhibitor-1

Synonym: CLK1/2 IN 2,CLK1/2IN2,CLK1/2-inhibitor-2,CLK1/2-IN-2,CLK1/2 inhibitor 2

Synonym: NCGC00188654,CID44968231

Target: IRAK, CDK, Haspin Kinase

EHT 1610

T15204

Synonym: EHT 5372

Target: GSK-3, NF-κB, Tyrosinase, DYRK, CDK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01948	COQ7 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Ubiquinone biosynthesis protein COQ7 homolog, also known as Coenzyme Q biosynthesis protein 7 homolog, Timing protein clk-1 homolog and COQ7, is a mitochondrion inner membrane and peripheral membrane protein which bel...
TMPY-04404	DCLK1 Protein, Human, Recombinant (aa 1-705, His & GST)	Human	Baculovirus Insect Cells
	DCLK1 Protein, Human, Recombinant (aa 1-705, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 106 kDa and the accession number is O15075-1.
TMPY-04752	DCLK1 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	DCLK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 78.5 kDa and the accession number is O15075-1.
TMPY-04546	CLK3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Dual specificity protein kinase CLK3, also known as CDC-like kinase 3, and CLK3, is a member of CMGC Ser/Thr protein kinase family and Lammer subfamily. Mammalian CLK is the prototype for a family of dual specificity ...