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Search Results for " cd80 "

9

Compounds

Cat No. Product Name Synonyms Targets
T10722 CD80-IN-3 Bombesin Receptor
CD80-IN-3 is a potent CD80 inhibitor and inhibits CD80/CD28 interaction (Kd: 125 nM; EC50: 630 nM).
T80598 Davoceticept CD80 vIgD-Fc,ALPN-202
Davoceticept (ALPN-202; CD80 vIgD-Fc), a monoclonal antibody that targets CTLA-4, is comprised of the (1-107) fragment of CD80 fused to the IGHG1 Fc domain through a peptidyl linker. It is commonly produced in CHO (Chine...
T11126 Durvalumab MEDI 4736 PD-1/PD-L1
Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and 0.04 nM, respectively. Durvalumab is often used in combinat...
T76809 Galiximab
Galiximab (IDEC 114), a primatized IgG1 lambda monoclonal antibody, targets the CD80 antigen. It combines primatized (cynomologous monkeys) variable regions with human constant regions. This compound is utilized in the s...
T73642 PD-1/PD-L1-IN 3 TFA
PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, serves as a potent and selective inhibitor of PD-1/PD-L1 interaction. This compound disrupts PD-L1's binding with PD-1 and CD80 by directly binding to PD-L1, exhibiting IC50 va...
T74915 ODN D-SL03
ODN D-SL03, a class C CpG oligonucleotide, effectively stimulates peripheral blood mononuclear cells (PBMCs) to produce high levels of IFN-α. It activates human B cells, NK cells, and mononuclear cells, elevating the exp...
TN5912 Macluraxanthone 3-Hydroxyblancoxanthone Antioxidant , TNF
Macluraxanthone (3-Hydroxyblancoxanthone) has many biological activities including anticholinesterase, antioxidant, anticancer, antimalarial, anti-inflammatory and immunomodulatory effects. macluraxanthone promotes the p...
T83866 LCC-12 formate
LCC-12, a derivative of the biguanide metformin, acts as a copper (II) chelator. It efficiently forms a monomeric bond with copper (II) and at 20 µM, it mitigates hydrogen peroxide-induced oxidation from NADH to NAD+. At...
T36984 Cyclic di-IMP (sodium salt)
Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with ...
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