Aquaporin

Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to reduce ischaemic brain oedema.

TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.

DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor, with an IC50 of approximately 0.1-0.4 μM for both mouse and human AQP3. It demonstrates selectivity for AQP3 compared to homologous AQP subtypes AQP7 and AQP9.

p-Tolylmaleimide (p Tolylmaleimide) is an inhibitor of the water channel and binds to Aquaporin Z.

Z433927330 is a potent and selective Aquaporin-7 (AQP7) inhibitor (IC50 of 0.2).

TGN-073 is an enhancer of aquaporin 4 (AQP4), a water channel in astrocytes. It shows an increase in lymphatic transport in the rat brain by up to 41%.

RF03176 is an inhibitor of aquaporin-9 (AQP-9) and also shows moderate inhibitory effects on mAQP3 and mAQP7. It exhibits no activity against mAQP8.

Nicotinanilide (N-Phenylnicotinamide) (Compound 12) acts as an inhibitor of aquaporin 4 (AQP4). It is applicable in research focused on diseases associated with AQP4 dysfunction, such as epilepsy and migraines.

TC-AQP1-1 is a blocker of the aquaporin 1 channel identified by virtual screening and inhibits water flux through hAQP1 in Xenopus laevis oocyte swelling assays at low micromolar concentrations.

AER-271 is an inhibitor of aquaporin-4.

Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.

AQP4 (205-215) is a fragment of the water channel protein Aquaporin-4 (AQP4). This protein is an autoimmune antigen in optic neuromyelitis and, upon binding with CD40, is upregulated and presented in B cells. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).

AqF026 is an AQP1 agonist that enhances AQP1-mediated water transport. It is utilized in research related to peritoneal dialysis and diseases associated with local water metabolism defects, such as subretinal edema and cerebral edema.

Betamethasone acetate, the 21-acetate ester of betamethasone, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.

HTS13286 is a novel inhibitor of AQP9. It can prevent lipopolysaccharide-induced increases in NO and reduce glucose output. HTS13286 is applicable for research in endotoxin shock.

PROTAC BCL6/GSPT1 Degrader-1 is a dual-target PROTAC degrader aimed at BCL6 and GSPT1. It inhibits cell proliferation, promotes DNA damage, and induces cell cycle arrest and apoptosis (apoptosis) in diffuse large B cell lymphoma. PROTAC BCL6/GSPT1 Degrader-1 is applicable for research in tumors such as lymphoma.

1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. 4. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation.

1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF-beta1 pathway. 3. Aristololactam I may be one of toxic metabolites in Chinese herbs containing AA which participate in renal damage and fibrosis.

AQP3-IN-1 (compounds 3), an AQP3 inhibitor, exhibits an IC 50 of 8.91 μM and effectively inhibits melanoma cell proliferation [1].

RG100204 is an orally active AQP9 inhibitor with anti-inflammatory properties. It alleviates cardiac dysfunction (systolic and diastolic) induced by sepsis, improves renal dysfunction, and reduces the elevation of the cellular damage marker LDH.

Betamethasone Acetate (Standard) is the standard substance of Betamethasone Acetate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Betamethasone acetate, the 21-acetate ester of betamethasone, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.

AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. This compound can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal abnormalities, and lesions at the grey/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.

AQP4 (201-220) is the encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal lesions, and lesions at the gray matter/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.

AQP4 (205-215) TFA is a fragment of the water channel protein-4 (AQP4). AQP4 acts as an autoimmune antigen in neuromyelitis optica, upregulating and presenting in B cells upon binding with CD40. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).