α-estradiol

Estradiol (β-Estradiol) hemihydrate, a key female sex hormone and steroid, plays a significant role in up-regulating neural markers in human endometrial stem cells (hEnSCs) and facilitating their neural differentiation. It is also utilized in research focused on cancers, neurodegenerative diseases, and neural tissue engineering.

β-Estradiol-6-CMO-PEG3-biotin serves as a cleavable 3-unit PEG ADC linker for the synthesis of antibody-drug conjugates (ADCs) [1].

β-Estradiol-6-one 6-(O-carboxymethyloxime) is an alkyl chain-based PROTAC linker used for PROTAC synthesis [1].

3-O-methyl Estradiol is a synthetic estrogen known for its ability to interfere with microtubule networks in V79 Chinese hamster cells, with an EC50 value of 9 µM. At a concentration of 20 µM, it inhibits the proliferation of these cells by 92%. Additionally, when male rats on a high-cholesterol diet are administered 3-O-methyl Estradiol (25 mg in a 0.2 ml solution, p.o.), it results in decreased serum cholesterol levels and increases body weight loss, suggesting feminizing effects. It has also been utilized as a standard for quantifying 17β-estradiol in hen urine.

Ethynyl estradiol 3-sulfate (17α-Ethynylestradiol-3-sulfate; EE-3-SO4) has been shown to extend the median survival time by approximately sixfold and achieve an 80% survival rate at six hours in a rat model of acute severe hemorrhage.

Estradiol 3-sulfate 17β-Glucuronide potassium salt (Estradiol 3-sulfate 17-glucuronide potassium) is a naturally occurring estrogen that competitively inhibits MRP-mediated LTC transporter and can be used to study metabolic diseases.

17β-Estradiol sulfate sodium (17β-Estradiol 3-sulfate sodium) is a neuroactive estrogen with vasoprotective properties that inhibits the growth of Neisseria brasiliensis and disrupts aquatic ecosystems.

Estradiol enanthate is a useful organic compound for research related to life sciences. The catalog number is T65147 and the CAS number is 4956-37-0.

Estradiol-3-Glucuronide-d3 is the deuterated form of Estradiol-3-Glucuronide and can be used for isotope tracing.

2-Methyl estradiol is an endogenous metabolite of estradiol that inhibits cell proliferation and angiogenesis. The IC50 values for its effects on the proliferation of HUVEC (human umbilical vein endothelial cells) and MCF-7 (human breast cancer cells) are 3 μM and 2.39 μM, respectively.

Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.

Estradiol benzoate (Benzhormovarine) is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.

Estradiol (E2) is a naturally occurring steroidal sex hormone that is essential for female fertility and maintenance of secondary sexual characteristics. Estradiol upregulates IL-6 expression through estrogen receptor beta (ERβ).

Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.

Promestriene (3-propyl ethyl) (INN) is a synthetic estrogen and glucocorticoid used topically in a 1% cream formulation. It is described as a tropic agent and antiseborrheic.

Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.

Estradiol 3-sulfamate (BLE 00084) is an orally active and highly potent steroidal estrone sulfatase (ES) inhibitor.Estradiol 3-sulfamate has a K(i) value of 73 nM for ES in human placental microsomes and can be used in the study of breast cancer.

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.

Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

Mestranol (Devocin), a semisynthetic estrogen, is used as an estrogen receptor agonist and must be demethylated to be biologically active.

beta-Estradiol 17-hemisuccinate selectively stains estrogen receptor (ER)-rich cells.

Estradiol 3-glucuronide is an immunogen with antigenic properties. The antiserum induced in rabbits exhibits high affinity and specificity for Estradiol 3-glucuronide. This compound shows promise for use in research involving radioimmunoassay.

Estradiol undecylate can be used in the treatment of prostatic cancer.