Simaroubaceae

Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.

Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml.

Bruceine E is isolated from B. javanica seeds with hypoglycemia effects. Bruceine E can be used for studies about acting as an insulin secretagogue.

Bruceine A (NSC-31616)(NSC-310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.

Ailanthone (AIL) is a natural compound derived from the tree Ailanthus altissima and has anti-hepatocellular carcinoma (HCC) properties. It can induce G0/G1 phase cell cycle arrest by downregulating the expression of cyclins and CDKs, while upregulating the expression of p21 and p27. Additionally, Ailanthone is a potent androgen receptor (AR) inhibitor, capable of inhibiting both the full-length androgen receptor (IC50: 69 nM) and constitutively active splice variants (IC50: 309 nM).

1. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW199 and CAPAN-1; induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway.

Yadanzioside F is a quassinoid and terpenoid extracted from the seed of Crowberry (Brucea javanica), which is lethally toxic to mice and has the potential to inhibit the enzyme InhA (Mycobacterium enoyl acyl carrier protein reductase) and to act as an antituberculosis (TB) agent.

Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.

Pasakbumin B (13-alpha-(21)-Epoxyeurycomanone) is a bioactive compound from Eurycoma longifolia Jack.

Yadanziolide A is a natural product isolated from the cultivated dry seeds of Brucea javanica, has strong antiviral activities with IC50 of 5.5 μM against tobacco mosaic virus. Yadanziolide A shows significant antitumor effects.

14,15 β-Dihydroxyklaineanone(14,15beta-Dihydroxyklaineanone) is a bittersweet compound isolated from Eurycoma longifolia with antitumor-promoting, antischistosomal and plasmodium-killing activities.

Yadanziolide B, a bitter wood bittersweet analog from the stem of Brucea mollis, is cytotoxic with an IC50 value of 3.00-5.81 μM.

Strophanthidin (Strophanthidine) can induce calcium overload in vivo.

Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-induced degradation of IκBα or the phosphorylation of IKKα/β and IκBα.

Bruceantin (NSC-165563) is a natural product isolated from Brucea antidysenterica. Bruceantin has antitumor activity against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.

Yadanzioside C is a quassinoid and terpenoid extracted from Brucea javanica that has the potential to inhibit InhA enzyme (Mycobacterium enoyl acyl carrier protein reductase) and to act as an anti-tuberculosis (TB) drug potential.

Yadanzioside G is a quassinoid and terpenoid extracted from Brucea javanica with antipancreatic cancer activity, inhibition of InhA enzyme (Mycobacterium enoyl acyl carrier protein reductase) and potential as an anti-tuberculosis (TB) drug.

Yadanzioside A is a quassinoid and terpenoid extracted from Brucea javanica with antipancreatic cancer activity, inhibition of InhA enzyme (Mycobacterium enoyl acyl carrier protein reductase) and potential as an anti-tuberculosis (TB) drug.

Bruceantinol has antiviral activity, it can inhibit pepper mottle virus in pepper; it shows antibabesial activity against Babesia gibsoni in vitro, with the IC50 value of 12 ng/mL.

Bruceoside A is a bitter wood glycoside that can be isolated from opuntia and has anticancer and tumor activity and can be used with the study of leukemia.

Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccharide-stimulated HUVEC and T cell adhesion to TNF-stimulated HUVEC.

1-Methoxycarbonyl-β-carboline (1-Methoxycarbonyl-beta-carboline) is an alkaloid from Ailanthus altissima.

Nigakinone, isolated from Kumu, is an alkaloid with the pharmacological activity.

Bruceoside B, a triterpenoid saponin from Brucea javanica, has potential anticancer activity, inhibits InhA enzyme (Mycobacterium enoyl acyl carrier protein reductase) and acts as an anti-tuberculosis agent.