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Natural Product Categories Natural Product Categories Sapindales
Sapindales is an order of flowering plants that includes economically and medicinally important families such as Rutaceae, Sapindaceae, and Anacardiaceae, encompassing citrus, maple relatives, and cashew. Members of Sapindales are rich in diverse secondary metabolites, including limonoids, flavonoids, alkaloids, and essential oils. In biomedical research, Sapindales is highly significant due to its strong antimicrobial, anticancer, anti-inflammatory, and metabolic regulatory activities. Citrus-derived flavonoids and limonoids, for example, are widely studied for cardiovascular and immune-modulating effects. The order also plays a major role in pharmacognosy and nutraceutical development due to its combination of edible, aromatic, and medicinal species.
- RocaglamideRocaglamide A, Roc-ATQ013184573-16-0Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.
- $166
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- BrusatolNSC 172924, (+)-BrusatolTQ021114907-98-3Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
- $33
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Cited - NobiletinHexamethoxyflavoneT2834478-01-3Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa).
- $52
SizeQTY Cited - Azadirachtin BDeacetylazadirachtinol, 3-TigloylazadirachtolT14368106500-25-8Azadirachtin B (Deacetylazadirachtinol) is a terpenoid compound isolated from Azadirachta seeds, with insecticidal, anticancer, anti-inflammatory, antitumor, and antiviral activities, useful in the study of viral infections. Azadirachtin B also has osteoblast proliferation, differentiation, and mineralization properties.
- $123
SizeQTY - EURYCOMANONEPasakbumin AT702784633-29-4Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20 μg/ml.
- $40
SizeQTY Cited - Pilocarpine HydrochloridePilocarpine HCl, NSC 5746 HCl, (+)-Pilocarpine hydrochlorideT080454-71-7Pilocarpine Hydrochloride (NSC 5746 HCl) is an M3-type muscarinic acetylcholine receptor agonist. Pilocarpine Hydrochloride is used to generate experimental models of epilepsy.Inquiry Cited
- Bruceine ETN112821586-90-3Bruceine E is isolated from B. javanica seeds with hypoglycemia effects. Bruceine E can be used for studies about acting as an insulin secretagogue.
- $46
SizeQTY Cited - NaringeninS-Dihydrogenistein, Salipurol, Pelargidanon, NSC 34875, NSC 11855, NaringetolT2838480-41-1Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
- $50
SizeQTY Cited - Bruceine ANSC31616, DihydrobrusatolT2S204625514-31-2Bruceine A (NSC-31616)(NSC-310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.
- $51
SizeQTY - SalidrosideRhodiolosideT271710338-51-9Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor. Salidroside can alleviate cachexia symptoms in a tumor cachexia mouse model by activating mTOR signaling and protect dopaminergic neurons by enhancing PINK1/Parkin-mediated mitochondrial autophagy. Salidroside can also inhibit the growth of cancer cells by regulating the CDK4-cyclin D1 pathway to block the G1 phase and/or regulating the Cdc2-cyclin B1 pathway to block the G2 phase.
- $30
SizeQTY Cited - AilanthoneΔ13-DehydrochaparrinoneTQ0209981-15-7Ailanthone (AIL) is a natural compound derived from the tree Ailanthus altissima and has anti-hepatocellular carcinoma (HCC) properties. It can induce G0/G1 phase cell cycle arrest by downregulating the expression of cyclins and CDKs, while upregulating the expression of p21 and p27. Additionally, Ailanthone is a potent androgen receptor (AR) inhibitor, capable of inhibiting both the full-length androgen receptor (IC50: 69 nM) and constitutively active splice variants (IC50: 309 nM).
- $36
SizeQTY Cited - Urolithin M5Decarboxyellagic acidT8431891485-02-8Urolithin M5 (Decarboxyellagic acid) is a neuraminidase inhibitor isolated from olive leaves with antiviral and anticancer and antitumor activities. Urolithin M5 can be used to study influenza A virus infection and SARS-CoV-2 infection.
- $56
SizeQTY Cited - AKBAAcetyl-11-keto-β-boswellic acid, 3-O-Acetyl-11-keto-β-boswellic acid, 3-O-Acetyl-11-keto-beta-boswellic acidT5S156967416-61-9AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.
- $32
SizeQTY Cited - Bruceine DTWS204521499-66-11. Bruceine D from Brucea javanica, may have the potential to be used as a natural viricide, or a lead compound for new viricides. 2. Bruceine D inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW199 and CAPAN-1; induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway.
- $41
SizeQTY Cited - EriocitrinEriodictyol-7-O-Rutinoside, Eriodictyol glycoside, eriodictyol 7-rutinoside, EriodictiosideT6S022113463-28-01. Eriocitrin (Eriodictyol-7-O-Rutinoside) is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in a rat model of high-fat diet. 2. Dietary Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. 3. Eriocitrin and Apigenin were identified as new potent inhibitors of human carbonic anhydrase VA isozyme.
- $31
SizeQTY Cited - Yadanzioside FTN526695258-11-0Yadanzioside F is a quassinoid and terpenoid extracted from the seed of Crowberry (Brucea javanica), which is lethally toxic to mice and has the potential to inhibit the enzyme InhA (Mycobacterium enoyl acyl carrier protein reductase) and to act as an antituberculosis (TB) agent.
- $229
SizeQTY - Hydroxy-α-sanshoolHydroxy-α-sanshoolT830783883-10-7Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
- $68
SizeQTY - Aurantiamide acetateAsperglaucideTJS221656121-42-7Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].
- $106
SizeQTY - AzadirachtinTN141711141-17-6Azadirachtin has antifungal activity, used as an insecticide.
- $58
SizeQTY - RutinRutoside, Quercetin 3-O-rutinosideT0795153-18-4Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
- $36
SizeQTY Cited - IsoscoparinTN180320013-23-4Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and treatment of obesity.
- $68
SizeQTY - PhellamurinTN476152589-11-4Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellode
- $166
SizeQTY - HesperetinT2565520-33-2Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
- $36
SizeQTY Cited - HarmaneLoturine, Harman, AribineT3158486-84-0Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.
- $49
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