ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.

Cat. No.	Product name	CAS No.	Purity
T16855	SB-772077B dihydrochloride	607373-46-6	98%
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
T35328	H-1152 dihydrochloride	871543-07-6	98%

T13972	Y-9738	59399-41-6	98%
Y-9738 is an agent of hypolipidemic.
TN1533	Cucurbitacin A	6040-19-3	98%
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
T15808	Merestinib dihydrochloride	1206801-37-7	98%
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
T1606	Fasudil	103745-39-7	98%
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T7552	H-1152	451462-58-1	98%
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T7492	Ripasudil free base	223645-67-8	98%
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T13364	YAP/TAZ inhibitor-1	2093565-23-0	98%
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
TQ0183	Narciclasine	29477-83-6	98%
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T9652	SB-747651A Dihydrochloride	1781882-72-1	98%
SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...
T12747	ROCK2-IN-2	1995065-79-6	98%
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
T23308	SAR407899 hydrochloride	923262-96-8	98%
ATP-competitive ROCK inhibitor
T7885	Afuresertib hydrochloride	1047645-82-8	100%
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
TQ0319	Ripasudil	887375-67-9	100%
Ripasudil (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
T19913	CKI-7	1177141-67-1	100.00%
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
TQ0110	ROCK-IN-2	867017-68-3	97.59%
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
T7301	BDP5290	1817698-21-7	98%
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T2482	AT13148	1056901-62-2	98.04%
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T2633	GSK429286A	864082-47-3	98.42%
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T16855

SB-772077B dihydrochloride

607373-46-6

98%

SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).

T35328

H-1152 dihydrochloride

871543-07-6

98%

T13972

Y-9738

59399-41-6

98%

Y-9738 is an agent of hypolipidemic.

TN1533

Cucurbitacin A

6040-19-3

98%

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...

T15808

Merestinib dihydrochloride

1206801-37-7

98%

Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...

T1606

Fasudil

103745-39-7

98%

Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

T7552

H-1152

451462-58-1

98%

H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).

T7492

Ripasudil free base

223645-67-8

98%

Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.

T13364

YAP/TAZ inhibitor-1

2093565-23-0

98%

YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).

TQ0183

Narciclasine

29477-83-6

98%

Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.

T9652

SB-747651A Dihydrochloride

1781882-72-1

98%

SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...

T12747

ROCK2-IN-2

1995065-79-6

98%