ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.

Cat. No.	Product name	CAS No.	Purity
T23888	CID-5056270	681173-76-2	98%
CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, ...
T11402L	GKI-1 HCl	T11402L	98%
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
T10888	CRT0066854 hydrochloride	2250019-91-9	98%
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
T7492	Ripasudil free base	223645-67-8	98%
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T13364	YAP/TAZ inhibitor-1	2093565-23-0	98%
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
T13972	Y-9738	59399-41-6	98%
Y-9738 is an agent of hypolipidemic.
T16855	SB-772077B dihydrochloride	607373-46-6	98%
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
TN1533	Cucurbitacin A	6040-19-3	98%
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
T15808	Merestinib dihydrochloride	1206801-37-7	98%
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
T15798	LX7101	1192189-69-7	98%
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T7552	H-1152	451462-58-1	98%
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
TQ0187	SR-3677	1072959-67-1	98%
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T7391	SAR407899	923359-38-0	98%
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T12746	ROCK inhibitor-2	1127308-52-4	98%
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T1870	Y-27632	146986-50-7	98%
Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
T4276	Hydroxyfasudil Hydrochloride	155558-32-0	98%
Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T4095	ZINC00881524	557782-81-7	98%
ZINC00881524 is an effective and specific ROCK inhibitor.
T1911	Afuresertib	1047644-62-1	98%
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T1898	RKI-1447	1342278-01-6	98%
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
TQ0183	Narciclasine	29477-83-6	98%
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T23888

CID-5056270

681173-76-2

98%

CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, ...

T11402L

GKI-1 HCl

T11402L

98%

GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.

T10888

CRT0066854 hydrochloride

2250019-91-9

98%

CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...

T7492

Ripasudil free base

223645-67-8

98%

Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.

T13364

YAP/TAZ inhibitor-1

2093565-23-0

98%

YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).

T13972

Y-9738

59399-41-6

98%

Y-9738 is an agent of hypolipidemic.

T16855

SB-772077B dihydrochloride

607373-46-6

98%

SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).

TN1533

Cucurbitacin A

6040-19-3

98%

Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...

T15808

Merestinib dihydrochloride

1206801-37-7

98%

Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...

T15798

LX7101

1192189-69-7

98%

LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).

T7552

H-1152

451462-58-1

98%