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ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78205 ROCK2-IN-6 hydrochloride 2762238-94-6 98%
ROCK2-IN-6 hydrochloride
ROCK2-IN-6 hydrochloride (Comp A) serves as a selective inhibitor of ROCK2, applicable for research into ROCK-mediated diseases, autoimmune disorders, and inflam...
T79077 ROCK-IN-6 2489328-74-5 98%
ROCK-IN-6
ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1]....
T79080 ROCK-IN-7 2376635-95-7 98%
ROCK-IN-7
ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].
T79809 ROCK-IN-8 1621103-79-4 98%
ROCK-IN-8
ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research, demonstrat...
T79832 ROCK2-IN-6 2260506-59-8 98%
ROCK2-IN-6
ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1].
T79833 ROCK-IN-9 2643334-76-1 98%
ROCK-IN-9
ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM. It demonstrates favorable pharmacokinetic properties i...
T79905 Akt/ROCK-IN-1 98%
Akt/ROCK-IN-1
Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively. It possesses antitumor efficacy aga...
T81261 ROCK2-IN-7 3000541-95-4 98%
ROCK2-IN-7
ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis. It exhibits its efficacy in targeting ROCK2 enzymes within HaCaT ...
T82766 CCG-232964 2349373-70-0 98%
CCG-232964
CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].
T7492 Ripasudil free base 223645-67-8 98%
Ripasudil free base
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T13364 YAP/TAZ inhibitor-1 2093565-23-0 98%
YAP/TAZ inhibitor-1
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
T13972 Y-9738 59399-41-6 98%
Y-9738
Y-9738 is an agent of hypolipidemic.
T16855 SB-772077B dihydrochloride 607373-46-6 98%
SB-772077B dihydrochloride
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
TN1533 Cucurbitacin A 6040-19-3 98%
Cucurbitacin A
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
TN1985 Neoprzewaquinone A 630057-39-5 98%
Neoprzewaquinone A
Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 ...
T15808 Merestinib dihydrochloride 1206801-37-7 98%
Merestinib dihydrochloride
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
T7552 H-1152 451462-58-1 98%
H-1152
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T10358 Netarsudil Dihydrochloride 1253952-02-1 99.98%
Netarsudil Dihydrochloride
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective...
T3060 Fasudil hydrochloride 105628-07-7 99.98%
Fasudil hydrochloride
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
TQ0187 SR-3677 1072959-67-1 99.91%
SR-3677
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
ROCK2-IN-6 hydrochloride
T78205
ROCK2-IN-6 hydrochloride (Comp A) serves as a selective inhibitor of ROCK2, applicable for research into ROCK-mediated diseases, autoimmune disorders, and inflam...
ROCK-IN-6
T79077
ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1]....
ROCK-IN-7
T79080
ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].
ROCK-IN-8
T79809
ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research, demonstrat...
ROCK2-IN-6
T79832
ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1].
ROCK-IN-9
T79833
ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM. It demonstrates favorable pharmacokinetic properties i...
Akt/ROCK-IN-1
T79905
Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively. It possesses antitumor efficacy aga...
ROCK2-IN-7
T81261
ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis. It exhibits its efficacy in targeting ROCK2 enzymes within HaCaT ...
CCG-232964
T82766
CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].
Ripasudil free base
T7492
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
YAP/TAZ inhibitor-1
T13364
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
Y-9738
T13972
Y-9738 is an agent of hypolipidemic.
SB-772077B dihydrochloride
T16855
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
Cucurbitacin A
TN1533
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
Neoprzewaquinone A
TN1985
Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 ...
Merestinib dihydrochloride
T15808
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
H-1152
T7552
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
Netarsudil Dihydrochloride
T10358
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective...
Fasudil hydrochloride
T3060
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
SR-3677
TQ0187
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
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TargetMol