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ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Cat. No. Product name CAS No. Purity Chemical Structure
T16855 SB-772077B dihydrochloride 607373-46-6 98%
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
T35328 H-1152 dihydrochloride 871543-07-6 98%
T13972 Y-9738 59399-41-6 98%
Y-9738 is an agent of hypolipidemic.
TN1533 Cucurbitacin A 6040-19-3 98%
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
T15808 Merestinib dihydrochloride 1206801-37-7 98%
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
T1606 Fasudil 103745-39-7 98%
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T7552 H-1152 451462-58-1 98%
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T7492 Ripasudil free base 223645-67-8 98%
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T13364 YAP/TAZ inhibitor-1 2093565-23-0 98%
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
TQ0183 Narciclasine 29477-83-6 98%
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T9652 SB-747651A Dihydrochloride 1781882-72-1 98%
SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...
T12747 ROCK2-IN-2 1995065-79-6 98%
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
T23308 SAR407899 hydrochloride 923262-96-8 98%
ATP-competitive ROCK inhibitor
T7885 Afuresertib hydrochloride 1047645-82-8 100%
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
TQ0319 Ripasudil 887375-67-9 100%
Ripasudil (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
T19913 CKI-7 1177141-67-1 100.00%
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
TQ0110 ROCK-IN-2 867017-68-3 97.59%
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
T7301 BDP5290 1817698-21-7 98%
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T2482 AT13148 1056901-62-2 98.04%
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T2633 GSK429286A 864082-47-3 98.42%
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
SB-772077B dihydrochloride
T16855
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
H-1152 dihydrochloride
T35328
Y-9738
T13972
Y-9738 is an agent of hypolipidemic.
Cucurbitacin A
TN1533
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
Merestinib dihydrochloride
T15808
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
Fasudil
T1606
Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
H-1152
T7552
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
Ripasudil free base
T7492
Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
YAP/TAZ inhibitor-1
T13364
YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
Narciclasine
TQ0183
Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
SB-747651A Dihydrochloride
T9652
SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...
ROCK2-IN-2
T12747
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
SAR407899 hydrochloride
T23308
ATP-competitive ROCK inhibitor
Afuresertib hydrochloride
T7885
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
Ripasudil
TQ0319
Ripasudil (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
CKI-7
T19913
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
ROCK-IN-2
TQ0110
Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
BDP5290
T7301
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
AT13148
T2482
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
GSK429286A
T2633
GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
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