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Immunology/Inflammation NOD

NOD

The nucleotide-binding oligomerization domain-like receptors, or NOD-like receptors (NLRs), are intracellular sensors of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that are associated with cell stress. They are types of pattern recognition receptors (PRRs), and play key roles in the regulation of innate immune response. NLRs can cooperate with toll-like receptors (TLRs) and regulate inflammatory and apoptotic response. They are found in lymphocytes, macrophages, dendritic cells and also in non-immune cells, for example in epithelium. NLRs are highly conserved through evolution. Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance R protein)
Cat No. product name
T9222 Emlenoflast Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.
T4217 INF39 INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
T3230 NLRP3 Inflammasome Inhibitor I It is a NLRP3 Inflammasome Inhibitor I.
T3701 MCC950 CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and ca...
T6887 MCC950 sodium MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.
T0109 Molsidomine Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO)...
T0122 Bengenin Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T2845 Imperatorin Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
T6591 ML130 Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T4164 CY09 CY-09 is an NLRP3 inhibitor.
T5838 L-Canavanine sulfate L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
T13378 Z-Asp-CH2-DCB Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.
T6S1367 Procyanidin B2 Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inf...
T7597 6-Biopterin 6-Biopterin is a natural product,is a NO synthase cofactor.
T7682 Asymmetric dimethylarginine Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS)
T3092 Nigericin sodium salt Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi func...
TQ0165 Arglabin Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
TQ0165 Arglabin Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
TN1273 4',7-Dihydroxyflavone 4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
T15052 Dapansutrile Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
T3587 NOD-IN-1 NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
Emlenoflast
T9222CAS 1995067-59-8
Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.
INF39
T4217CAS 866028-26-4
INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
NLRP3 Inflammasome Inhibitor I
T3230CAS 16673-34-0
It is a NLRP3 Inflammasome Inhibitor I.
MCC950
T3701CAS 210826-40-7
CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and ca...
MCC950 sodium
T6887CAS 256373-96-3
MCC950 sodium salt (IC50 of 7.5 nM in BMDMs) is an effective, selective NLRP3 inhibitor.
Molsidomine
T0109CAS 25717-80-0
Molsidomine is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO)...
Bengenin
T0122CAS 477-90-7
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
Imperatorin
T2845CAS 482-44-0
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
ML130
T6591CAS 799264-47-4
Nodinitib-1 is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
CY09
T4164CAS 1073612-91-5
CY-09 is an NLRP3 inhibitor.
L-Canavanine sulfate
T5838CAS 2219-31-0
L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
Z-Asp-CH2-DCB
T13378CAS 153088-73-4
Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.
Procyanidin B2
T6S1367CAS 29106-49-8
Procyanidin B2 has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inf...
6-Biopterin
T7597CAS 22150-76-1
6-Biopterin is a natural product,is a NO synthase cofactor.
Asymmetric dimethylarginine
T7682CAS 30315-93-6
Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS)
Nigericin sodium salt
T3092CAS 28643-80-3
Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi func...
Arglabin
TQ0165CAS 84692-91-1
Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
Arglabin
TQ0165CAS 84692-91-1
Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
4',7-Dihydroxyflavone
TN1273CAS 2196-14-7
4',7-Dihydroxyflavone can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.
Dapansutrile
T15052CAS 54863-37-5
Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
NOD-IN-1
T3587CAS 132819-92-2
NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.