T3646 |
RSL3
|
1219810-16-8
|
99.23%
|
|
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that ...
|
T36935 |
PKUMDL-LC-101-D04
|
2143896-83-5
|
98.71%
|
|
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control ...
|
T8375 |
ML-210
|
1360705-96-9
|
97%
|
|
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
|
T21899 |
Misonidazole
|
13551-87-6
|
95.00%
|
|
Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.
|
T77745 |
N6F11
|
851398-76-0
|
98%
|
|
N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cance...
|
T77755 |
GPX4-IN-5
|
2922824-09-5
|
98%
|
|
GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces iron death and can be used for the prevention an...
|
T77759 |
GPX4-IN-6
|
2922824-07-3
|
98%
|
|
GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces iron death and is used for the treatment= and pr...
|
T8970 |
ML162
|
1035072-16-2
|
98%
|
|
ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-typ...
|
T19117 |
3-Deoxyglucosone
|
4084-27-9
|
98%
|
|
3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein a...
|
T37314 |
JKE-1674
|
2421119-60-8
|
98%
|
|
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
|