Home Tools
Log in
Cart

GPX

Glutathione peroxidase (GPx) is an important peroxide disintegrating enzyme widely present in the organism.The active center of GSx is selenocysteine, and the amount of its activity can reflect the selenium level of the organism. Selenium is a component of the GSx enzyme system, which catalyzes the change of GSH to GSSG and the reduction of toxic peroxides to non-toxic hydroxyl compounds, thus protecting the structure and function of cell membranes from the interference and damage caused by peroxides.The reduction of NADPH is linearly correlated with the activity of glutathione peroxidase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3646 RSL3 1219810-16-8 99.23%
RSL3
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that ...
T36935 PKUMDL-LC-101-D04 2143896-83-5 98.71%
PKUMDL-LC-101-D04
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control ...
T8375 ML-210 1360705-96-9 97%
ML-210
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
T21899 Misonidazole 13551-87-6 95.00%
Misonidazole
Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.
T77745 N6F11 851398-76-0 98%
N6F11
N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cance...
T77755 GPX4-IN-5 2922824-09-5 98%
GPX4-IN-5
GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces iron death and can be used for the prevention an...
T77759 GPX4-IN-6 2922824-07-3 98%
GPX4-IN-6
GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces iron death and is used for the treatment= and pr...
T8970 ML162 1035072-16-2 98%
ML162
ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-typ...
T19117 3-Deoxyglucosone 4084-27-9 98%
3-Deoxyglucosone
3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein a...
T37314 JKE-1674 2421119-60-8 98%
JKE-1674
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
RSL3
T3646
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that ...
PKUMDL-LC-101-D04
T36935
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control ...
ML-210
T8375
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
Misonidazole
T21899
Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.
N6F11
T77745
N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cance...
GPX4-IN-5
T77755
GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces iron death and can be used for the prevention an...
GPX4-IN-6
T77759
GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces iron death and is used for the treatment= and pr...
ML162
T8970
ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-typ...
3-Deoxyglucosone
T19117
3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein a...
JKE-1674
T37314
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
TargetMol